度洛西汀与艾司西酞普兰治疗老年抑郁症对照研究  

Comparative Study of Duloxetine versus Escitalopram in the Treatment of Elderly Depression

作　　者：高良会[1] 颜景祥[1] 张扬[1] 杨老虎[1] 

机构地区：[1]中国．河北省第六人民医院,保定071000

出　　处：《中国健康心理学杂志》2011年第9期1029-1030,共2页China Journal of Health Psychology

摘　　要：目的观察度洛西汀与艾司西酞普兰治疗老年抑郁症的疗效及安全性。方法 64例老年抑郁症患者随机分为度洛西汀组（31例）和艾司西酞普兰组（33例）,治疗剂量分别为30~60m g/d和10~15m g/d,观察6周。用汉密尔顿抑郁量表（HAM D）评定疗效,用不良反应量表（TESS）评估不良反应和安全性。结果治疗第6周末度洛西汀组和艾司西酞普兰组的有效率分别为77%（24/31）和76%（25/33）,差异无统计学意义（χ2=0.10,P〉0.05）;临床痊愈率分别为52%（16/31）和55%（18/33）,差异无统计学意义（2χ=0.25,P〉0.05）。治疗第1周末,度洛西汀组起效率为35%（11/31）,与艾司西酞普兰组36%（12/33）相比差异无统计学意义（2χ=0.14,P〉0.05）。不良反应发生比例大于10%的度洛西汀组为便秘、失眠和食欲降低,艾司西酞普兰组为失眠和疲劳。结论度洛西汀和艾司西酞普兰对老年抑郁症患者同样安全有效。Objective To observe the efficacy and safety of Duloxetine and Escitalopram in elderly depression.Methods A total of 64 patients with episode depression were randomly divided into Duloxetineg roup（n=31） and Escitalopram group（n=33）.The patients were treated with Duloxetine（30~60mg/d） or Escitalopram（10~15mg/d） for 6 weeks.The efficacy was assessed with Hamilton depression rating scale（HAMD 17） and the side effects were assessed with Treatment Emergent Symptoms Scale（TESS）.Results The efficacy rates of the Dulixetine subgroup and the Escitalopram subgroup were 77% and 76%,there was no significant difference between two subgroups（χ2=0.10,P0.05）.after 6-weeks of treatment.The clinical recovery rate was 52% in duloxetine group and 55% in Escitalopram group,with no difference（χ2=0.25,P0.05）.After the first week of treatment,the response rate was 35% in Duloxetine group and 36% in Escitalopram group without difference（χ2=0.14,P0.05）.The reported adverse frequent rate being above 10% were constipation,insomnia,inappetence in Duloxetine group and insomnia,fatigue in Escitalopram group.Conclusion Duloxetine and Escitalopram are both effective and safe in elderly patients with depressive disorder.

关 键 词：度洛西汀 艾司西酞普兰 抑郁症 老年 

分 类 号：R971.43[医药卫生—药品]