睡眠剥夺影响脑执行功能的心理生理研究  

Psychological and physiological impact of 36 h total sleep deprivation on the executive function of the brain

作　　者：邵永聪[1] 叶恩茂[1] 王富贵[1] 毕国华[1] 靳霄[1] 杨征[1] 

机构地区：[1]军事医学科学院基础医学研究所全军军事认知与心理卫生研究中心,北京100850

出　　处：《军事医学》2011年第9期666-671,共6页Military Medical Sciences

基　　金：军队“十一五”重点指令性课题（06Z066）

摘　　要：目的研究36 h完全睡眠剥夺（total sleep deprivation,TSD）对脑执行控制功能的影响。方法试验采用自身前后对照设计,对14名健康男性进行Go/Nogo测验,同时进行事件相关电位（event-related potentials,ERP）记录及功能性磁共振成像（functional magnetic resonance imaging,fMRI）扫描。结果 36 h睡眠剥夺后受试者的正确击中率明显下降,错误反应率显著增高。ERP结果显示：（1）TSD使Nogo-N2和Nogo-P3波幅下降,潜伏期延长;（2）经过8 h的恢复性睡眠,Nogo-N2和Nogo-P3的波幅与TSD后相比有所恢复,但未恢复至基线水平。fMRI结果显示,SD后前扣带回皮质（anterior cingulate cortex,ACC）活动降低,前额叶皮质活动明显增强。结论 36 h睡眠剥夺导致脑执行控制功能的显著下降,前额叶皮质出现功能代偿是维持机体认知作业的重要特征。8 h恢复性睡眠可以使脑执行控制功能得到部分恢复,但并不能恢复至基线水平。Objective To study the impact of 36 h total sleep deprivation（TSD） on the executive control function of the brain.Methods Healthy young men（n=14） undergoing the visual Go/Nogo task before and after 36 h sleep deprivation were studied with event related potentials（ERP） and functional magnetic resonance imaging（fMRI）.Results The hit rate of Go/Nogo task decreased and the false alarm rate increased after 36 h sleep deprivation.TSD induced decreased the amplitude,but enhanced the latency of Nogo-N2 and Nogo-P3 on Fz and Nogo-P3 on Cz electrode.The latency of the recovery value of Nogo-N2 and Nogo-P3 was statistically significant compared to the baseline.TSD-induced positive and negative blood oxygenation level-dependent（BOLD） signals were compared with those after a normal night′s sleep（NORM）.The activated areas with positive BOLD signals included the superior prefrontal cortex and inferior prefrontal cortex while those with negative BOLD signal were in the anterior cingulate cortex（ACC） and right lingual gyrus.Conclusion The executive control function of the brain is decreased after 36 h TSD.The increased activation of PFC might be related to the compensatory response since more attention resources are needed to perform the Go/Nogo task after 36 h TSD.The recovery sleep can effectively regain the impacted executive function.

关 键 词：睡眠剥夺 脑执行功能 事件相关电位 功能性磁共振成像 

分 类 号：R338.63[医药卫生—人体生理学]