5-HT_(1A)受体激动和5-HT重摄取抑制双靶标新药YL-0919抗抑郁作用的药效学评价  

Antidepressant-like effects of YL-0919,a novel dual-acting antidepressant with 5-HT_(1A) receptor agonist and serotonin reuptake inhibitor

作　　者：陈红霞[1] 徐晓丹[1] 薛瑞[1] 袁莉[1] 杨日芳[1] 李云峰[1] 

机构地区：[1]军事医学科学院毒物药物研究所全军军事认知与心理卫生研究中心,北京100850

出　　处：《军事医学》2011年第9期676-680,共5页Military Medical Sciences

基　　金：国家自然科学基金资助项目(81102423;81173036;81001653)

摘　　要：目的评价兼有5-HT1A受体激动和5-HT重摄取抑制双靶标化合物YL-0919的抗抑郁作用,并在靶标水平探讨其作用机制。方法和结果在小鼠悬尾和小鼠强迫游泳实验中,YL-0919(1.25,2.5,5 mg/kg,ig)能够显著地缩短小鼠悬尾不动时间和游泳不动时间,5-HT1A受体拮抗剂WAY100635(0.3 mg/kg,sc)能够完全拮抗YL-0919(2.5 mg/kg,ig)在小鼠悬尾实验中的抗抑郁作用;在药物诱发抑郁模型上,YL-0919增强5-羟色氨酸(5-hydroxytryptophan,5-HTP,120 mg/kg,ip)诱导的小鼠甩头行为,但不能拮抗高剂量阿扑吗啡(16 mg/kg,sc)诱导的降温作用;YL-0919在抗抑郁有效剂量范围内对小鼠的自主活动性无显著性影响。结论新型双靶标新药YL-0919具有明确的抗抑郁作用,此作用与激动5-HT1A受体,增强5-HT系统的功能有关。Objective To investigate the antidepressant-like effect and possible mechanism of YL-0919,a novel dual-acting antidepressant with 5-HT1A receptor agonist and serotonin reuptake inhibitor.Methods and Results In the tail suspension test and forced swimming test in mice,YL-0919（1.25,2.5 and 5 mg/kg,ig）significantly decreased the immobility time.5-HT1A receptor antagonist（WAY100635,0.3 mg/kg,sc） could completely prevent the antidepressant-like effect in the tail suspension test.In the 5-hydroxytryptophan（5-HTP,120 mg/kg,ip） potentiation test,YL-0919 significantly increased the symptom of head-twitches induced by 5-HTP.However,YL-0919 had no significant effect on the apomorphine（16 mg/kg,sc）induced hypothermia or the locomotor activity in mice.Conclusion YL-0919 produces reliable antidpressant-like effect,which may be attributed to the activation of 5-HT1A receptor and the potentiation of 5-HT system.

关 键 词：双靶标 5-HT1A受体激动剂 5-HT重摄取抑制剂 抗抑郁药物 

分 类 号：R96[医药卫生—药理学]