栀子厚朴汤配伍变化对柚皮素与橙皮素药代动力学的影响  

Effect of different formula compatibility of Zhizi Houpu decoction on the pharmacokinetics of naringenin and hesperetin

作　　者：孙丽丽[1] 冯芳[1,2] 赵孝蕊[1] 

机构地区：[1]中国药科大学药物分析教研室,南京210009 [2]中国药科大学药物质量与安全预警教育部重点实验室,南京210009

出　　处：《中国药科大学学报》2011年第5期431-435,共5页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.30973858)~~

摘　　要：研究大鼠灌胃给予枳实、枳实-栀子、枳实-厚朴和栀子厚朴汤4种配伍汤剂后柚皮素与橙皮素在血浆中的药代动力学。将SD大鼠随机分为4组,分别灌胃枳实、枳实-栀子、枳实-厚朴、栀子厚朴汤剂10.83 mL/kg,采用HPLC法测定各汤剂给药后的血药浓度,计算药代动力学参数。结果表明4种不同配伍方给药后,柚皮素与橙皮素的药代动力学参数有差异。栀子厚朴汤不同配伍对柚皮素与橙皮素在大鼠血浆中的药代动力学存在不同的影响。栀子或厚朴能够延缓柚皮素与橙皮素的达峰时间;厚朴能够显著地增加橙皮素的AUC0-24 h;枳实、栀子、厚朴3味药材共同配伍应用时减少了柚皮素与橙皮素的达峰时间,使柚皮素的AUC0-24 h降低,同时使橙皮素的AUC0-24 h增加,但增加程度低于枳实-厚朴组。实验结果显示药材配伍对相同成分的药代动力学行为有影响。The objective of this paper was to obtain pharmacokinetic parameters from concentration-time data of naringenin and hesperetin in rat plasma after oral administration of different recipes of Zhizi Houpu decoction （ZZHPD） which contained HP （ Magnoliae Officinalis Cortex）, ZS （ Aurantii Fructus Immaturus） and ZZ （ Gar- deniae Fructus）, including ZS, ZS-ZZ （ ZS and ZZ）, ZS-HP （ ZS and HP） and ZZHPD （ ZS, ZZ and HP）. The effects of different recipes of ZZHPD on the pharmacokinetics of naringenin and hesperetin in rat plasma were investigated. Twenty-four rats were randomly divided into four groups, and treated with ZS, ZS-ZZ, ZS-HP and ZZHPD （ 10. 83 mL/kg）, respectively. The plasma concentrations of four recipes were determined by HPLC, and the pharmacokinetic parameters of naringenin and hesperetin in these recipes were evaluated. The pharmacokinetic parameters of naringenin and hesperetin were different after oral administration of four decoctions according to ZS combined with different herbal medicines. ZZ and HP could delay the absorption of naringenin and hesperetin, and HP could significantly increase the AUC0_24 h of hesperetin; the compatible effect of herbs in ZZHPD could accelerate the absorption rate of naringenin and hesperetin, reduce the AUC0_24 h of naringenin and increase the AUCo-24 h of hesperetin with the enhaneive extend less than that of ZS-HP group. The pharmacokinetic parameters of the two compounds obtained in this work showed that the pharmacokinetics of naringenin and hesperetin were influenced diversely when ZS was combined with different herbal medicines.

关 键 词：栀子厚朴汤 配伍 柚皮素 橙皮素 HPLC 药代动力学 

分 类 号：R285.5[医药卫生—中药学]