聚乙烯吡咯烷酮-花锚总苷固体分散体及体外溶出特性考察  

Study on PVP-total glucosides of Halenia elliptica solid dispersion and the dissolution in vitro

作　　者：王业清[1] 史可丽[1] 廖志新[1] 纪兰菊[2] 孙洪发[2] 

机构地区：[1]东南大学化学化工学院,江苏南京210009 [2]中国科学院西北高原生物研究所,青海西宁810001

出　　处：《中国医院药学杂志》2011年第20期1664-1667,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金资助(编号:30770233);青海省重点攻关项目(编号:2008-G-136)

摘　　要：目的:制备聚乙烯吡咯烷酮(PVP-k30)-花锚总苷固体分散体,提高花锚总苷的溶解性,并观察其微观形态。方法:利用溶剂法制备PVP-花锚总苷固体分散体,利用紫外分光光度计法进行溶出度测定,利用扫描电镜(SEM)和X射线粉末衍射(XRD)分析固体分散体中花锚总苷分散状态。结果:利用溶剂法成功制备PVP-花锚总苷固体分散体。与花锚总苷相比,制备的PVP-花锚总苷固体分散体中花锚苷的溶出度具有明显增加,且溶出度随着载体的质量比例增加而增大。SEM与XRD结果表明,花锚总苷与载体PVP以低共溶物形式存在于固体分散体中。结论:以PVP-k30为载体,制备PVP-花锚总苷固体分散体可有效改善花锚总苷的溶出性能。OBJECTIVE To prepare the PVP total glucosides of H. elliptica D. Don （TGH） Solid dispersion （SD） for im proving the dissolution. The SD microcosmic morphology was also observed. METHODS PVP-TGH SDs were prepared by solvent method. The dissolution rate in vitro were studied by UV spectrophotometer. Scanning electron micrograph （SEM） and Xray powder diffraction （XRD） were used to analyze the characteristics of TGH and PVP in SDs. RESULTS The SDs were prepared successfully. Compared with the dissolution rate of haleniaside of TGH, the SDs dissolution rate of haleniaside increased obviously, and the dissolution rate became higher by the increasing of carrier ratio. According to SEM and XRD, the drug and PVP were existed as eutectic in the SDs. CONCLUSION The SD technique can be used for increasing the dissolution rate of TGH.

关 键 词：花锚总苷 固体分散体 聚乙烯吡咯烷酮 扫描电子显微镜 X射线粉末衍射 溶出度 

分 类 号：R94[医药卫生—药剂学]