更昔洛韦联合中药复方治疗婴儿巨细胞病毒性肝炎的疗效观察  

Combined treatment of ganciclovir and Chinese herb compound for treatment of cytomegalovirus hepatitis in infants

作　　者：王蔚华[1] 鄢素琪[1] 邓玉萍[1] 汤建桥[1] 

机构地区：[1]武汉市儿童医院,湖北武汉430016

出　　处：《中国医院药学杂志》2011年第20期1719-1720,1730,共3页Chinese Journal of Hospital Pharmacy

基　　金：2007年武汉市临床重点科研项目(编号:武卫[2007]43号)

摘　　要：目的:研究中药复方联合更昔洛韦治疗婴儿巨细胞病毒性肝炎的临床疗效。方法:按随机分组法将60名巨细胞病毒性肝炎患儿分为2组,对照组30例,治疗组30例。2组均使用更昔洛韦治疗。治疗组在此基础上加用中药复方治疗。4周后复查血清TBIL、ALT、AST、TBA、γ-GT,观察肝脾回缩情况,并将2组患儿住院时间进行比较。结果:治疗4周后,治疗组血清TBIL、ALT、AST、TBA明显下降,γ-GT明显升高,与对照组比较有显著差异(P<0.05或P<0.01)。治疗组肝脾回缩情况明显优于对照组。治疗组住院时间明显短于对照组。结论:更昔洛韦联合中药复方治疗婴儿巨细胞病毒性肝炎疗效好,住院时间短。OBJECTIVE To observe the effect of combined treatment of ganciclovir and Chinese herb compound for treatment of infant cytomegalovirus hepatitis in clinic. METHODS The children with cytomegalovirus hepatitis were divided into two groups at random： treatment group and control group. The two groups were both treated with protection of liver and nutritional support. In the treatment group, the Chinese herb compound was added. The changes of liver function were observed, and the hospitalized time of the two groups was compared. RESULTS Compared with the control group, the levels of TBIL, ALT, AST, TBA and the hospitalized time were markedly decreased in the treatment group （P〈0. 05, P〈0. 01 ）. The difference was obviously significant. CONCLUSION Good effects and the shorter hospitalized time can be obtained by the combination of ganciclovir and Chinese herb compound in the treatment of infant cytomegalovirus hepatitis.

关 键 词：更昔洛韦 中药复方 婴儿巨细胞病毒性肝炎 

分 类 号：R969.4[医药卫生—药理学]