丙种球蛋白联合环孢素A、雄激素治疗再生障碍性贫血临床观察  

Clinical Observation of Immunoglobulin Combined with Cyclosporin A and Androgen for the Treatment of Aplastic Anemia

作　　者：周明[1] 肖佩玲[1] 罗科玲[1] 陈建军[1] 

机构地区：[1]湖南省人民医院血液科,湖南长沙410005

出　　处：《医学临床研究》2011年第9期1665-1667,共3页Journal of Clinical Research

摘　　要：[目的]探讨大剂量丙种球蛋白（HD-IVIgG）联合环孢素A（CsA）和雄激素对重型再生障碍性贫血（SAA）的疗效.[方法]静脉输注HD-IVIgG[0.4 g/（kg·d）]联合康力龙、CsA治疗SAA 21例（A组）,只使用康力龙和CsA治疗SAA 28例（B组）.观察两组疗效,并对疗效和一些相关因素进行比较.[结果]A组治疗有效率为90.5%,显著高于B组（60.7%）（P〈0.05）.A组的骨髓增生度及外周血网织红细胞的恢复优于B组.[结论]大剂量HD-IVIgG联合康力龙、CsA治疗SAA疗效显著,值得临床应用.[Objective]To explore the efficacy of high dose of immunoglobulin（HD-IVIgG） combined with cyclosporin A（CsA） and androgen for the treatment of aplastic anemia（AA）. [Methods] Among 49 AA patients, 21 patients received intravenous HD-IVIgG, stanozol and CsA, and 28 patients received only stanozol and CsA. The efficacy and correlation factors were observed and compared between two groups. [Results] The effective rate of the group with the combination of HD-IVIgG, stanozol and CsA was 90.5% which was higher than that of the group without immunoglobulin（60. 7%） （ P 〈 0.05）. Bone marrow hyperplasity and the recovery of reticulocytes in peripheral blood in the group with the combination of HD-IVIgG, stanozol and CsA were better than the group without immunoglobulin. [Conclusion]The efficacy of the combination of HD-IVIgG, stanozol and CsA for the treatment of AA is better than that of the combination of only stanozol and CsA, so it is more effective method for the treatment of AA.

关 键 词：贫血 再生障碍性/药物疗法 丙种球蛋白类/投药和剂量 环孢菌素/投药和剂量 雄激素类/投药和剂量 

分 类 号：R556.5[医药卫生—血液循环系统疾病]