胸水中IL-18、IFN-γ和ADA检测对结核性和恶性胸水的鉴别诊断价值  

Diagnostic Value of IL-18, IFN-γ and ADA in Differentiating Tuberculous Pleural Effusion from Malignant Pleural Effusion

作　　者：毛福青 何穗 

机构地区：[1]湘潭市中心医院检验科,湖南湘潭411100

出　　处：《医学临床研究》2011年第9期1748-1749,共2页Journal of Clinical Research

摘　　要：[目的]探讨白细胞介素-18（IL-18）,γ-干扰素（IFN-γ）和腺苷脱氨酶（ADA）对结核性和恶性胸水的鉴别诊断价值.[方法]将胸水标本分为结核性胸水组和恶性胸水组,用酶联免疫吸附法（ELISA）检测IL-18和IFN-γ水平,用酶速率法检测ADA 水平.[结果] 结核性胸水组中IL-18、IFN-γ和ADA水平均显著高于恶性胸水组（P〈0.01）.IL-18界值为82.92 pg/mL时,敏感度为82.8%,特异性为92.3%.IFN-γ界值为50.78 pg/mL时,敏感度为82.8%,特异性为92.3%.ADA界值为38.35 U/L时,敏感度为82.8%,特异性为94.9%.[结论]胸水中IL-18、IFN-γ和ADA检测对结核性胸水和恶性胸水有鉴别诊断意义.[Objective]To explore the diagnostic value of interleukin-18（IL-18）, interferon-γ（IFN） and adenosine deaminase （ADA） in differentiating tuberculous pleural effusion from malignant pleural effusion. [Methods] The specimens of pleural effusion were divided into tuberculous pleural effusion group and malignant pleural effusion group. Enzyme linked immunosorbent assay（ELISA） was used to detect the levels of IL- 18 and IFN-γ, and enzyme kinetic method was used to determine the level of ADA. [Results] The levels of IL- 18, IFN-γ and ADA in tuberculous pleural effusion group were significantly higher than those in malignant pleural effusion group（ P〈0.01）. When the cutoff value of IL-18 was 82.92pg/mL, its sensitivity and specificity was 82.80//00 and 92.3%, respectively. When the cutoff value of IFN-γ was 50.78pg/ml, its sensitivity and specificity was 82.8% and 92.3%, respectively. When the cutoff value of ADA was 38.35U/L, its sensitivity and specificity was 82.8 % and 94.9 %, respectively. [Conclusion] IL-18, IFN-γ and ADA are helpful for differentiating tuberculous pleural effusions from malignant pleural effusions.

关 键 词：胸膜积液 恶性/诊断 白细胞介素18 干扰素Ⅱ型 

分 类 号：R734.3[医药卫生—肿瘤]