2型糖尿病患者动态动脉硬化指数与颈动脉硬化及其危险因素关系研究  

Correlations of ambulatory arterial stiffness index with carotid atherosclerosis and its risk factors in the patients with type 2 diabets mellitus

作　　者：张维波[1] 傅强[1] 陈成[2] 江晨[1] 

机构地区：[1]福建省福州市第一医院内二科,350009 [2]福建省第二人民医院老年科

出　　处：《中国现代医药杂志》2011年第10期23-26,共4页Modern Medicine Journal of China

摘　　要：目的探讨2型糖尿病患者动态动脉硬化指数与颈动脉硬化及其危险因素的相关性。方法收集2型糖尿病患者共103例(T2DM组),非糖尿病患者41例为对照组(NDM组)。测定两组动态动脉硬化指数(AASI)、颈动脉内膜中层厚度(IMT)、体重指数(BMI)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、同型半胱氨酸(HCY)及超敏C反应蛋白(hs-CRP)、收缩压(SBP)、舒张压(DBP)、脉压差(PP)、甘油三酯(TG)、总胆固醇(TC)、高密度胆固醇(HDL-C)及低密度胆固醇(LDL-C),并对T2DM组进行相关性分析。结果 T2DM组患者的IMT、AASI、FPG、HCY及hs-CRP与NMD组比较有非常显著性差异(P<0.01),HbA1c有显著性差异(P<0.05)。2型糖尿病患者ASSI与IMT、糖尿病病程、FPG、HbA1c、SBP、PP、TC、LDL-C、HCY、hs-CRP等呈正相关关系。多元逐步回归分析提示2型糖尿病患者ASSI与IMT、HbA1c、PP、HCY、hs-CRP等有独立的相关关系(偏回归系数r分别为0.413、0.362、0.279、0.301、0.322,均为P<0.01)。结论 2型糖尿病患者ASSI与IMT、HbA1c、PP、HCY、hs-CRP等密切相关。Objective To investigate the correlations of ambulatory arterial stiffness index （AASI） with carotid atherosclerosis and its risk factors in the patients with type 2 diabets mellitus （T2DM）. Methods 103 patients with T2DM were enrolled in T2DM group, and 41 patients without DM were enrolled in control group （NDM group）. AASI,intima-media thickness（IMT）, systolic blood pressure （SBP）,diastlic blood pressure （DBP）,pulse pressure （PP）were determined. The levels of fasting plasma glucose （FPG）, HbAlc, homocysteine （HCY）, high sensitivity C -reative protein （hs-CRP）, triglycerides （TG）, total cholesterols （TC）,high densty lipid cholesterols （HDL-C） and low densty lipid cholesterols （LDL-C） were assayed, and body mass index （BMI） was calculated. Linear correlation and multiple linear regression were employed to analyze patients with T2DM. Results The IMT,AASI and the levels of FPG,HCY,hs-CRP in T2DM gourp were very significantly higher than the NDM group （P〈0.01）,the level of HbAlc was significantly different between the groups （P〈0.05）. There were postive correlations between AASI and IMT,duration of T2DM and the levels of FPG,HbAlc,SBP, PP, TC,LDL-C,HCY and hs-CRP in patients with T2DM, after adjustment of the other risks, there were independent relationship among AASI with IMT and the levels of HbAlc, PP,HCY,hs-CRP （the standardized partial regression coefficients were 0.413,0.362,0.279,0.301,0.322,all P〈0.01）. Conclusion AASI associates with IMT and the levels of HbAlc,PP, HCY or hs-CRP are significantly in patients with T2DM.

关 键 词：2型糖尿病 动态动脉硬化指数 颈动脉硬化 危险因素 

分 类 号：R587.1[医药卫生—内分泌] R543.4[医药卫生—内科学]