正常妊娠与不明原因早期自然流产蜕膜组织SOCS-3的表达与差异  

SOCS-3 expressions in decidual tissues from normal pregnancy and early spontaneous abortion with unknown causes and the difference in the expressions

作　　者：马艳芬[1] 张秀果[1] 

机构地区：[1]广东医学院附属厚街医院妇产科,东莞523960

出　　处：《国际医药卫生导报》2011年第19期2370-2374,共5页International Medicine and Health Guidance News

摘　　要：目的观察不同类型自然流产组织中SOCS-3的表达与差异，探讨SOCS-3与自然流产的关系及其在妊娠中的作用。方法应用荧光定量PCR（Real—timePCR）法分析正常组及自然流产各组中SOCS-3mRNA的表达及差异。结果SOCS-3在蜕膜组织中均有表达，正常组相对表达量为（1．000±0．000）；先兆流产组蜕膜组织中SOCS-3表达量可见显著降低，表达量为（0．578±0．097）；难免流产组表达继续下降，表达量为（0．231-t-O．017）；而稽留流产组表达量明显升高，表达量为（1．469±0．033）；各组间差异具有显著性（P〈0．05）。结论表明SOCS-3在妊娠的维持中具有一定的作用。Objective To observe SOCS-3 expressions and their difference in tissues from different types of spontaneous abortion, and to explore the correlation of SOCS-3 with spontaneous abortion and the role of SOCS-3 in pregnancy. Methods The expressions and difference of SOCS-3 mRNA in decidual tissues from normal pregnancy and different types of spontaneous abortion with unknown causes were detected by real-time PCR. Results SOCS-3 mRNA expressions were detectable in all the decidual tissues. SOCS-3 mRNA expression level was （ 1.000 ±0.000） in normal group; SOCS-3 mRNA expression level was significantly lower in threatened abortion group than in normal control group （ 0.578 ±0.097, P 〈 0.05 ） and it continued to decline in ineitable abortion group （ 0.231 ±0.017, P 〈 0.05 ）; but it was significantly elevated in missed abortion group （ 1.469 ±0.033, P 〈 0.05 ）. Conclusions Our study has shown SOCS-3 plays a certain role in the maintenance of pregnancy.

关 键 词：自然流产 SOCS-3 蜕膜 妊娠 

分 类 号：R714.21[医药卫生—妇产科学]