神经节苷脂治疗新生儿缺氧缺血性脑病60例临床疗效观察  

作　　者：温博贤[1] 何杏勤[2] 林凤莲 

机构地区：[1]广州市中山大学附属第六医院儿科,510655 [2]广州市中山大学附属肿瘤防治中心神经泌尿科,510655 [3]广州市天河区妇幼保健院妇科门诊部,510655

出　　处：《当代医学》2011年第29期15-16,共2页Contemporary Medicine

摘　　要：目的观察神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将60例HIE患儿随机平分为治疗组和对照组。两组均给予常规支持、对症治疗,治疗组应用神经节苷脂静脉滴注,对照组应用胞二磷胆碱静脉滴注,两组患者各1次/d,疗程10～14d。结果治疗组治疗组显效9例(占30.0%),有效15例(50.0%),无效6例(20.0%),总有效率24例(占80%);对照组显效6例(10.0%),有效12例(30%),无效12例(40.0%),总有效率18例(占60.0%)。两组的总有效率比较有显著差异(P<0.05)。结论神经节苷脂是治疗新生儿缺氧缺血性脑病的有效药物,值得临床在新生儿缺氧缺血性脑病治疗中进一步研究推广。Objective To observe the ganglioside treatment of neonatal hypoxic ischemic encephalopathy （HIE） of clinical efficacy.Methods 60 patients with HIE randomly divided into treatment and control groups.Both groups were given regular support, symptomatic treatment, intravenous infusion of ganglioside treatment group, control group citicoline injection, two groups of patients and once a day, 10-14 d treatment .Results The treatment group in 9 cases （30.0%）, effective in 15 cases （50.0%）, 6 cases （20.0%）, the total effective rate in 24 cases （80%）; control group, markedly effective in 6 cases （10.0%）, effective in 12 cases （30%）, 12 cases （40.0%）, the total effective rate in 18 cases （60.0%）. The total effective rate two groups were significantly different （P 〈0.05）.Conclusion Ganglioside treatment of neonatal hypoxic ischemic encephalopathy effective drug, is worthy of neonatal hypoxic ischemic encephalopathy in the treatment of further promotion.

关 键 词：神经节苷脂 新生儿缺氧缺血性脑病 疗效观察 

分 类 号：R722.1[医药卫生—儿科]