同型半胱氨酸、维生素B12、叶酸及D-二聚体与原发性高血压相关性探讨  

To explorre the correlationship between homocysteine folic acid vitamin B12 D-dimer and primary hypertension

作　　者：帅虎[1] 梅敏[1] 刘凌[1] 

机构地区：[1]肇庆市第一人民医院检验科,526020

出　　处：《国际医药卫生导报》2011年第20期2539-2541,共3页International Medicine and Health Guidance News

摘　　要：目的探讨血清同型半胱氨酸、维生素B12、叶酸及D-二聚体与原发性高血压的相关性。方法75例原发性高血压患者根据中国高血压防治指南分为高血压1级（23例）、2级（28例）、3级（24例），另选正常健康对照组30例。测定各组血清同型半胱氨酸、维生素B12、叶酸及D-二聚体水平。结果同型半胱氨酸、D-二聚体与各级血压成正相关（r=0．78，0．45，P〈0．01），维生素B12叶酸与血压成负相关（r=-0．38，-0．35，P〈0．05）。高血压1、2、3级患者同型半胱氨酸水平[（12．35±4．21）μmol／L，（17．08±4．52）μmol／L，（31．75±8．50）μmol／L]均明显高于正常对照组[（9．22±2．43）μmol／L，P〈0．05l维生素B12水平[（260．15±86．25）ng／L，（246．35±72．30）ng／L，（222．23±65．25）ng／L]，叶酸水平[（7．50±2．50）μg/L，（6．45±2．05）μg／L，（5．89±1．85）μg／L]明显低于正常对照组[维生素B12（315．64±112．12ng／L），叶酸（8．62±2．77）μg／L，P〈0．05]。2、3级高血压患者D-二聚体水平[（0．49±0．28）μg／ml，（0．73±0．35）μg／ml]明显高于正常对照组[（0．27±0．16）μg／ml，P〈0．05]。结论Hey是高血压危险因素之一，联合测定Hey、叶酸、维生素B12、D-二聚体对高血压的预防、诊断和病情监控具有重要意义。Objective To explorre the correlationship between serum homocysteine （Hcy）, Folic Acid, Vitamin B12, D-dimer and Primary Hypertension. Method Selected 75 example patients with Primary Hypertension and 30 example healthy persons as comparison. According to（（ The Guidelines on Prevention and Management of hypertension in china 〉）, 75 Primary Hypertension patients were divided into three groups： hypertension stage 1 group（23 cases）, stage 2 group（28 cases）, and stage 3 group（24 cases）. The serum hcy, folic acid, vitamin B12, and D-dimer content of each group were detected. Result Hcy and D-dimer had a positive correlationship with the risk stratification in hypertension （r = 0.78, 0.45, P〈0.01）. Folic acid and vitamin B12 had a negative correlationship with the risk stratification in hypertension （r = -0.38,-0.35, P〈0.05）. The content of Hcy [stage 1 （ 12.35 ± 4.21 ） umol/L, stage 2 （ 17.08 ±4.52 ） umol/L, stage 3 （ 31.75 ± 8.50 ） umol/L] increased with the risk stratification comparing to nor- mal control group[（ 9.22 ± 2.43 ） umol/L, P〈0.05]. The serum folic acid [stage 1 （ 7.50 ± 2.50 ） ug/ L, stage 2 （ 6.45 ±2.05 ） ug/L, stage 3 （ 5.89 ± 1.85 ） ug/L] and vitamin B12[stage 1 （ 260.15 ± 86.25 ） ng/L, stage 2 （ 246.35 ± 72.30 ） ng/L, stage 3 （ 222.23 ± 65.25 ） ng/L] is decreased with the risk stratification comparing to normal control group [folic acid（ 8.62 ±2.77 ）ug/L, vitamin B12（ 315. 64 ± 112.12 ） ng/L, P〈0.05]. D-dimer of stage 2 group[（0.49± 0.28）ug/ml] and stage 3 group[（ 0.73 ± 0.35 ）ug/ml] increased with the risk stratification comparing to normal control group[（0.27 ± 0.16 ）ug/ml ,P〈0.05]. Conclusion Hey level is a possible independent risk factor of hypertension. United determination of hey, folie acid, vitamin B12, and D-dimer level has clinical significance for the prevention, diagnosis,and treatment of hypertension.

关 键 词：同型半胱氨酸 高血压 叶酸 维生素B12 D-二聚体 

分 类 号：R544.1[医药卫生—心血管疾病]