甲酸铵催化转移氢化法制备龙血素A和龙血素B  

Synthesis of Loureirin A and Loureirin B by Catalytic Transfer Hydrogenation with Ammonium

作　　者：方旭兵[1] 温秋玲[1] 孙强[1] 聂光辉[1] 高莹[1] 戴康[1] 

机构地区：[1]中南民族大学药学院,湖北武汉430074

出　　处：《广州化工》2011年第19期40-42,共3页GuangZhou Chemical Industry

基　　金：国家自然科学基金面上项目(项目编号:30973961/H2818)

摘　　要：利用催化转移氢化将查耳酮还原为二氢查尔酮,在反应中研究了以甲酸铵作为氢给予体,Pd/C为催化剂,不同溶剂,不同温度及催化剂的量对反应的影响,并对反应条件进行优化,产率在60%以上。此法与直接加氢还原法比较具有安全性高、反应温度低、设备要求低和选择性高、后处理简单等优点,该法在二氢查尔酮的制备中得到较好结果,具有较广泛的用途。Catalytic transfer hydrogenation was to used to reduce chalcone to dihydrochalcone.Using ammonium as hydrogen donor,Pd-C as catalyst,the effects of different agents,temperature and amount of catalyst to the reaction were studied,and the reaction conditions were optimized,with yeild of more than 60%.Compared with traditional catalytic hydrogenation,the present method showed its benefit on more safe,lower requirement on equipment,and higher selectivity.This method would widely applied in preparation of dihydrochalcone.

关 键 词：催化转移氢化 甲酸铵 二氢查尔酮 氢给予体 

分 类 号：TQ455.49[化学工程—农药化工]