原子吸收分光光度法测定口服甘草锌的血锌浓度及药代动力学研究  

STUDY ON THE DETERMINATION OF ZINC IN PLASMA AFTER ORAL ADMINISTRATION OF LICORZIN BY ATOMIC ABSORPTION SPECTROPHOTOMETRY AND THE PHARMACOKINETICS OF ZINC IN HEALTHY VOLUNTEERS

作　　者：张欣怡[1] 吴如金[2] 陈坚[1] 安登魁[2] 

机构地区：[1]新疆医学院药学系,乌鲁木齐830054 [2]中国药科大学,南京210009

出　　处：《药学学报》1990年第2期157-160,共4页Acta Pharmaceutica Sinica

摘　　要：甘草锌(1icorzin)是从豆科植物甘草(Glycyrrhiza uralensis Fisch.)根中提取的有效成分与锌盐结合而成的含锌药物(含锌约4～5%,甘草酸约25%)。该药在临床上主要用于补锌,并且对胃肠道的刺激明显小于国内常用的补锌剂硫酸锌。A rapid, accurate and sensitive atomic absorption spectrophotometry was established for the determination of zinc in plasma after oral administration of licorzin to healthy volunteers. The plasma sample diluted with de-ionized water (1:1) was determined directly. A 5% glycerol solution was used as the solvent of zinc standard solution. The recovery of the proposed method was 97.3±4.3%. The precisions(CV%) of within-day and dayto-day were less than 5%. The pharmacokinetics of zinc in healthy volunteers after oral administration of 2.5 g licorzin was studied. The results showed that an one-compartment model (K_a=K) was found in 10 healthy volunteers. The pharmacokinetic parameters were as follows:K_a=K=0.380h^(-1), T_(max)=2.7h, V=33.03 L, T_(1/2)=1.9h.

关 键 词：甘草 甘草锌 药代动力学 测定 

分 类 号：R969.1[医药卫生—药理学]