新二萜醌——红根草对醌  

A NEW DITERPENOID QUINONE SAPRIPARAQUINONE

作　　者：林隆泽[1] 王晓明[1] 黄秀兰 黄勇 

机构地区：[1]中国科学院上海药物研究所,上海200031

出　　处：《药学学报》1990年第2期154-156,共3页Acta Pharmaceutica Sinica

摘　　要：红根草Saluia prionitis Hance系唇形科鼠尾草属植物,为江南民间常用草药。全草治疗腹泻菌痢,扁桃腺炎,咽喉炎,并有抗结核麻疯作用,已从其中分到新天然产物红根草邻醌和丹参酮ⅡA,丹参酮Ⅰ等二十余个化合物。A new diterpenoid quinone, named sapriparaquinone (1) was isolated from the root of Salvia prionitis Hance. 1 was identified as 3-hy-droxy-6-methyl-2-(1-methyl)-5-(4-methylpenten-3-yl)-1, 4-naphthoquinone by spectral analysis and chemical transformation of saprorthquinone (2). 1 and 2 are 4,5-seco-5, 10-frideoabietane derivatives and must be biogenetically derived from an abietane structure. Like 2, 1 also showed cytotoxieity against P388 leukemia cells.

关 键 词：红根草 红根草对醌 

分 类 号：R284.2[医药卫生—中药学]