苯氧烷胺类化合物的合成及其抗高血压活性  

SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME PHENOXYALKYLAMINE COMPOUNDS

作　　者：夏霖[1] 倪沛洲[1] 宋武[1] 刘国卿[1] 钱家庆[2] 李蓓[2] 桂冠华[2] 

机构地区：[1]中国药科大学,南京210009 [2]同济医科大学,汉口430030

出　　处：《药学学报》1990年第2期150-153,共4页Acta Pharmaceutica Sinica

摘　　要：前以2,6-二甲基苯氧乙叉为母体合成了一系列化合物,其中1-(2,6-二甲基苯氧基-2-(3,4-二甲氧基苯乙胺)-丙烷盐酸盐(Ⅰ)有较强而特久的降压作用。进一步研究又表明它具有阻断α-肾上腺素受体并兼有钙拮抗作用。Nine new compounds were synthesized and tested for their α-adrenoceptor affinity and antihypertensive activity together with 5 other previously reported compounds. Compounds Ⅰ, Ⅱa, Ⅱb and Ⅲa showed high α-adrenoceptor affinity and strong antihypertensive activity.

关 键 词：苯氧烷胺类 降压活性 受体亲和力 

分 类 号：R966[医药卫生—药理学]