烯胺型四氢异喹啉季铵碱化合物的合成  

Synthesis of enamine-type tetrahydro isoquinoline quaternary ammonium base compounds

作　　者：孙默然[1] 张秋荣[1] 杨华[1] 

机构地区：[1]郑州大学药学院,河南郑州450001

出　　处：《化学研究与应用》2011年第10期1359-1363,共5页Chemical Research and Application

基　　金：国家自然科学基金项目资助(No.20502023)

摘　　要：1位酯基取代、氮上烷基取代的四氢异喹啉在与碘甲烷成盐后不发生通常的Stevens重排反应,而是酯基α位烯醇化后发生氧烷基化反应,生成了稳定的烯胺型四氢异喹啉季铵碱化合物,收率在90%以上,该类化合物为首次报道。When 1-carboxyl ester substituted and N-alkyl substituted tetrahydroisoquinoline compounds reacted with methyl iodide,the usual stevens rearrangements didn＇t occurred due to the α-enolization of carboxylate and the subsequent O-alkylation.So the stable enamine-type tetrahydroisoquinoline quaternary ammonium base compounds were formed with yields of 90%or more,which were reported for the first time.

关 键 词：季铵碱 四氢异喹啉 烷基化 Stevens重排 

分 类 号：O626.32[理学—有机化学]