槲寄生化学成分的研究——Ⅵ.槲寄生新甙Ⅵ中手性碳的绝对构型测定  

STUDIES ON THE CHEMICAL COMPONENTS OF VISCUMCOLORATUM Ⅵ.CHIRALITY OF THE ACYLGROUP OF VISCUMNEOSIDE Ⅳ

作　　者：孔德云[1] 李惠庭[1] 罗思齐[1] 雷兴翰 

机构地区：[1]上海医药工业研究院,上海200040

出　　处：《药学学报》1990年第5期349-352,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：本文采用降解及与已知构型的化合物进行对比的方法。In order to determine the absolute configuration of the chiral center of viscumneoside Ⅳ, which was isolated from Viscum coloratum (Kom) Nakai, (R, S)-mevalonolactone was synthesized as shown in scheme 1. Then treatment with(S) (-)-1-phenylethylamine in THF gave two diasteromeric amides, which were transformed into the monoacetates and separated by HPLC. The first eluted peak (tR10.07 min.)had the (R)-configuration and the second one the (S)-configuration (tR 11.20 min).Viscumneoside Ⅳ was treated with borane and hydrolyzed to give mevalonolactone which was treated with (S)-(-)-1-phenylethylamine in THF as mentioned above. The monoacetates of the resulting amides were subjected to HPLC. By comparison with the reference peaks, the absolute configuration at the acyl moiety of viscumneoside Ⅳ was shown to have the (R)-configuration.

关 键 词：槲寄生 槲寄生新甙VI 液相色谱 

分 类 号：R284.1[医药卫生—中药学]