金翼黄芪甙A的化学结构和绵毛黄芪甙ⅩⅤ及7,2′-二羟基-3′,4′二甲氧基异黄烷-7-O-β-D-葡萄糖甙二维核磁共振谱的研究  

THE STRUCTURE OF ASTRACHRYSOSID A AND THE STUDY OF 2D-NMR ON ASTRASIEVERSIANIN XV AND 7, 2'-DIHYDROXY-3',4'-DIMETHOXY- ISOFLAVANE-7-O-β-D-GLYCOSIDE

作　　者：王惠康[1] 何侃[1] 徐宏喜[1] 张志亮[2] 王映芬[2] 菊池彻 手塜康弘 

机构地区：[1]上海中医学院中药系,上海200032 [2]北京医科大学,北京100083 [3]日本富山医科药科大学和汉药研究所

出　　处：《药学学报》1990年第6期445-450,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：从金翼黄芪中分离出金翼黄芪甙A(Ⅰ),绵毛黄芪甙XV (Ⅱ),7,2′-二羟基-3′,4′-二甲氧基异黄烷-7-O-β-D-葡萄糖甙(Ⅲ),大豆皂甙Ⅰ,胡萝卜甙及β-谷甾醇。Ⅰ为新化合物,确定其结构为3-O-[α[-L-鼠李吡喃糖基(1→2)-D-木吡喃糖基]-环黄芪醇。并应用二维核磁共振相关谱对Ⅱ和Ⅲ的~1H和^(13)C化学位移信号进行了全面归属。Six compouns were isolated from the root of Astragalus chrysopterus Bunge. One of them was identified as a new triterpenoid glycoside, named astrachrysoside A. Its structure was elucidated as 3-O-[α-L-rhamnopyranosyl (1→2) β-D-xylopyranosyl]-cycloastragenol on the basis of physicochemical evidence and chemical reactions The others were shown to be known compounds, astrasieversianin ⅩⅤ (Ⅱ),7,2'-dihydroxy-3',4'-dimethoxy -isoflavane-7-O-β-D-glucoside (Ⅲ), soyasaponin Ⅰ, daucosterol and β-sitosterol. Full assignment of the chemical shift signals of Ⅱ and Ⅲ were estab-lished by various 2D-NMR techniques.

关 键 词：金翼黄芪 黄芪甙 异黄烷 核磁共振 

分 类 号：R284.1[医药卫生—中药学]