学生接种甲型H1N1流感疫苗免疫原性与持久性观察  

Observation on immunogenicity of pandemic influenza A (H1N1) vaccine and its persistence among students

作　　者：沈月根[1] 周建红[1] 顾谢君[1] 林勤[1] 

机构地区：[1]嘉兴市秀洲区疾病预防控制中心,浙江嘉兴314001

出　　处：《疾病监测》2011年第9期685-688,共4页Disease Surveillance

摘　　要：目的通过对学生接种甲型H1N1流感疫苗的免疫原性及持久性观察,为今后甲型H1N1流感疫苗的使用与免疫策略提供参考依据。方法选择辖区内某中学初三年级学生为研究对象,以知情自愿为原则,于上臂三角肌处接种一剂国产甲型H1N1流感疫苗,并于接种前、接种后1、3、6个月和1年采集血清,检测不同时间段甲型H1N1流感HI抗体情况。结果学生免前甲型H1N1流感HI抗体阳性率为35.68%,免后1个月HI抗体阳转率为75.14%,阳性率为92.43%,GMT(倒数)为177.42,增长9.32倍,免后1年HI抗体阳性率仍在84.21%、GMT(倒数)93.03水平。结论国产甲型H1N1流感疫苗具有较好的免疫原性与免疫持久性,免疫后1年不用再次免疫。Objective To understand the immunogenicity of pandemic influenza A（H1N1） vaccine and its persistence among students and provide scientific evidence for the future use of pandemic influenza A（H1N1） vaccine and development of immunization strategies.Methods The middle school students in Xiuzhou were selected on basis of informed consent,the students were given a injection of H1N1 vaccine manufactured in China.The blood samples were taken from them before vaccination and at 1,3,6 months and I year after vaccination to detect HI antibodies to pandemic influenza A（H1N1） virus at different phases.Results The positive rate of HI antibody was 35.68% among the students before vaccination.The positive conversion rate of HI antibody was 75.14% and the positive rate was 92.43% one month after vaccination.The GMT（reciprocal） was 177.42,an increase of 9.32 times.The antibody conversion rate remained to be 84.21% and the GMT（reciprocal） was 93.03 one year after vaccination,Conclusion The domestic H1N1 vaccine has good immunogenicity which can last for long time.There is no need to re-vaccinate one year later.

关 键 词：甲型H1N1流感疫苗 免疫原性 持久性 

分 类 号：R392[医药卫生—免疫学]