2-[对-(二甲氨基)苯乙烯]碘化甲基吡啶对实验性急性心肌缺血的保护作用  

PROTECTIVE EFFECT OF 2-[P-(DIMETHYLAMINO) STYRYL] PYRIDINE METHIODIDE (DSPM) ON ACUTE EXPERIMENTAL MYOCARDIAL ISCHEMIA

作　　者：魏苑[1] 周承明[1] 王晓雯[1] 王雪飞[1] 张克锦[1] 

机构地区：[1]新疆医学院药理教研室,乌鲁木齐830054

出　　处：《药学学报》1990年第11期807-810,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：于摘除心脏前1 h或4 h给予DSPM 5 mg╱kg,可预防大鼠离体心脏的缺血损伤,使缺血后恢复灌流的心脏心功能有显著恢复,尤以4h前用DSPM者更明显,DSPM 1.5～6mg╱kg可显著对抗Iso引起的小鼠心肌钙含量增加,6mg╱kg 还可减少正常心肌钙含量。提示DSPM有保护缺血心肌的作用,此作用可能与其钙拮抗作用有关。ip DSPM 5 mg/kg 1 or 4 h before excision of the heart was found to preyent damage to the heart due to global myocardial ischemia. Compared with the controls, the heart rate, coronary resistance, contractile force and edema of the heart were all greatly improved during the 60 min reflow after 25 min of no-flow, especialy the heart pretreated with DSPM 4 h prior to excision. In addition, DSPM 1.5, 6 mg/kg markedly reduced the myocardial Ca^(2+) content measured by isoproterenol in mice. DSPM at higher dosage also lowered the normal myocardial Ca^(2+) content. These results suggest that DSPM may have a protective effect on myocardial ischemia which might be associated with its calcium antagonistic action.

关 键 词：心肌缺血 钙拮抗剂 碘化甲基吡啶 

分 类 号：R542.2[医药卫生—心血管疾病]