下肢严重缺血的干细胞移植治疗  

Stem cell therapy for critical limb ischemia

作　　者：吴峰阶[1] 王巧云[2] 

机构地区：[1]滨州医学院附属医院胃肠外科,山东省滨州市256603 [2]滨州医学院基础学院,山东省滨州市256603

出　　处：《中国组织工程研究与临床康复》2011年第32期6060-6063,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:近年来研究发现干细胞移植疗法由于能增加新血管生成,促进侧支循环的建立,故有望成为严重下肢缺血的有效治疗措施,但少有文献就此方面进行综述和概括。目的:综述近年关于干细胞移植治疗下肢严重缺血的最新进展。方法:应用计算机检索2010-10/2011-01CNKI、PubMed数据库相关文章,检索词"肢体缺血,干细胞移植,血管新生,peripheral arterial disease,stem cells transplantation,neovascularzation"。共检索到文献68篇,最终纳入符合标准的文献24篇。结果与结论:严重下肢缺血是外周动脉疾病的终末期,对患者的生活质量产生很大影响,其中一部分患者已经失去血管重建的机会。干细胞移植疗法由于能增加新血管生成,促进侧支循环建立,从而成为严重下肢缺血患者保肢的新选择而备受关注。但其潜在的新血管生成机制尚需通过基础研究和临床大宗随机对照研究来进一步完善,以期使更多的下肢严重缺血患者受益。BACKGROUND： Recently, stem cell therapy focuses on augmenting neovascularisation and ameliorating collateraI circulation. And it will be a new limbsalving option for critical limb ischemia patients. However, there are few reviews on research progress and development direction. OBJECTIVE： To present a survey of recent publication concerning about stem cell therapy in patients with critical limb ischemia. METHODS： PubMed database and CNKI database were retrieved for publications of critical limb ischemia and stem cell therapy published from 2010-10 to 2011-01. The were ＂limb ischemia, stem cells transplantation, neovascularisation＂ in Chinese and ＂peripheral arterial disease, stem cells transplantation, neovascularzation＂ in English. Repetitive studies were excluded. A total of 68 literatures were primarily obtained, while 24 were selected for summarization according to inclusion criteria. RESULTS AND CONCLUSION： Critical limb ischemia is the end stage of peripheral arterial disease, with a deep impact on patient＇s quality of life. In some patients, there are no revascularizing treatment options. Stem cell therapy focusing on augmenting neovascularisation and ameliorating collateraI circulation has raised much interest in the past decade. It is a new limbsalving option for critical limb ischemia patients. However, the underlying mechanisms of neovascularization are still incompletely understood. Both fundamental research as well as large randomized trials are needed for further optimisation of this treatment option, and will hopefully lead to much more benefits for more critical limb ischemia patients in the near future.

关 键 词：肢体缺血 血管新生 干细胞移植 干细胞治疗 综述文献 

分 类 号：R318[医药卫生—生物医学工程]