丹参酮ⅡA对动脉粥样硬化大鼠VCAM-1表达的影响  

Effects of tanshinone Ⅱ A on expression of VCAM-1 in atherosclerotic mice

作　　者：黎洪展[1] 吕永恒[1] 陈琪[1] 黄光胜[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510315

出　　处：《中国老年学杂志》2011年第19期3736-3737,共2页Chinese Journal of Gerontology

基　　金：广东省中医药局基金(No.20100424)

摘　　要：目的研究丹参酮ⅡA(Tsn)对动脉粥样硬化(AS)大鼠VCAM-1表达的影响。方法采用高胆固醇饲料喂饲建立大鼠AS模型。测定各组血清中总胆固醇、甘油三酯及低密度脂蛋白胆固醇,免疫组化观察内膜粥样硬化斑块中VCAM-1的表达情况。结果 Tsn组内膜增生较模型组明显减轻。VCAM-1在Tsn组中表达较模型组明显减少(P<0.05)。结论 Tsn可明显抑制VCAM-1表达,此可能为其防治AS的机制之一。Objective To investigate the effects of tanshinone Ⅱ A on expression of VCAM-1 in atherosclerotic mice.Methods 30 mices were divided into three groups and loaded with different diet for 12 weeks.Blood samples were collected for examination of serum lipid levels,and the atherosclerotic plaque area on aortic tunica intima were measured and the expression of VCAM-1 were detected by immuno-histochemistry.Results There was no significantly differences in blood lipid level between Tanshinone Ⅱ A groups and AS model group（P〉0.05）.Compared with the AS model group,the plaque area in Tanshinone Ⅱ A group was significantly smaller.The expression of VCAM-1 of Tanshinone ⅡA group was decreased significantly than that of AS model group（P〈0.05）.Conclusions Tanshinone Ⅱ A could inhibit atherosclerotic progression,which may correlated with the decreased expression of VCAM-1.

关 键 词：丹参酮ⅡA 动脉粥样硬化 VCAM-1 

分 类 号：R541[医药卫生—心血管疾病]