非酒精性脂肪肝与冠心病严重性的相关性研究  

Nonalcoholic fatty liver disease related to the severity of coronary artery disease

作　　者：周小莉[1] 何兰杰[1] 毕鹏翔[2] 

机构地区：[1]宁夏医科大学附属心脑血管病医院内分泌科,银川750004 [2]黑龙江省牡丹江医学院附属红旗医院神经内科

出　　处：《中华内分泌代谢杂志》2011年第9期729-732,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的探讨非酒精性脂肪肝（NAFLD）与冠心病病变严重程度的相关性。方法采用回顾性横断面研究方法分析经冠状动脉造影明确的冠心病患者756例，其冠状动脉病变严重程度与NAFLD的关系。结果Logistic回归分析显示，高血压、NAFLD、糖尿病、吸烟史及γ-谷氨酰胺转肽酶增高、高密度脂蛋白胆固醇降低为冠心病多支病变及闭塞性病变的危险因素（P〈0．05或P〈0．01），总胆固醇及丙氨酸氨基转移酶增高为冠心病多支病变的危险因素（P〈0．05或P〈0．01），冠心病家族史为冠心病闭塞性病变的危险因素（P〈0．01）。NAFLD是冠心病多支病变及闭塞病变的独立危险因素（P〈0．05或P〈0．01）。结论NAFLD与冠心病多支病变及闭塞性病变显著相关，临床医师应重视对NAFLD的早期预防及诊治，以改善冠心病的发展及预后。Objective To investigate the relationship between nonalcoholic fatty liver disease（NAFLD） and the severity of coronary artery disease （ CAD ）. Methods Retrospective cross-sectional studies were conducted to examine the relationship between NAFLD and the severity of CAD. CAD was diagnosed by coronary angiography and NAFLD by type-B ultrasound. Results The logistic regression analysis showed that hypertension, NAFLD, diabetes, smoking, and high level of γ-glutamyhransferase were risk factors of multiple- vessel lesions and occlusion of CAD （ P〈0.05 or P〈0. 01 ） , and high levels of total cholesterol and alanine aminotransferase were risk factors of multiple-vessel lesions （ P〈0.05 or P〈0.01 ） , family history was a risk factor of occlusion of CAD, whereas, high level of high-density lipoprotein cholesterol was an important protective factor of multiple-vessel lesions and occlusion of CAD （ P 〈 0.01 ）. NAFLD was a dependent risk factor of multiple-vessel lesions and occlusion of CAD （ P〈0.05 or P〈0.01 ）. Conclusions NAFLD could be regarded as a main risk factor of the severity of CAD. Clinicians should pay more attention to the prevention and treatment of NAFLD in order to improve the outcome of CAD.

关 键 词：非酒精性脂肪肝 冠状动脉疾病 多支病变 闭塞性病变 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]