2型糖尿病患者口服糖耐量试验胰升糖素和生长抑素水平的变化  

Changes of glucagon and somatostatin levels during oral glucose tolerance test in patients with type 2 diabetes mellitus

作　　者：马莉敏[1] 夏芳珍[1] 朱惠[1] 陈奕[1] 余娇[1] 李影[1] 李艳香[1] 张惠新[1] 乔洁[1] 陆颖理[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院内分泌代谢科,200011

出　　处：《中华内分泌代谢杂志》2011年第9期749-751,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：检测60例2型糖尿病患者和34名正常对照者空腹及口服75g葡萄糖2h后胰升糖素、生长抑素（SS）和C肽水平。结果显示，与对照组比较，糖尿病组空腹胰升糖素、SS及糖负荷后2h SS明显降低（均P〈0．01），空腹及2hC肽明显升高（均P〈0．01）。两组糖负荷后2h激素水平均显著高于空腹（均P〈0．01），与对照组比较，糖尿病组胰升糖素（1．40±0．48对1．20±0．30，P〈0．05）和SS（2．79±2．17对1．14±0．22，P〈0．01）餐后增加倍数更高，C肽增加倍数较低（3．58±3．10对8．33±6．99，P〈0．01）；两组空腹胰升糖素水平与SS呈正相关（均P〈0．01）。以上结果提示，2型糖尿病患者不仅B细胞功能紊乱，尚存在α、δ细胞相关激素紊乱。The fasting and 2 h levels of glucagon, somatostatin （ SS ）, and C-peptide during 75 g oral glucose tolerance test in 60 patients with type 2 diabetes and 34 normal subjects were determined. Compared with control group, the fasting levels of glucagon and SS and 2 h levels of SS after glucose loading significantly decreased, while the fasting and 2 h levels of C-peptide increased in diabetes group. The 2 h levels of these hormones were significantly higher than the fasting levels in two groups. Compared with control group, the increased folds of glucagon （ 1.40±0.48 vs 1.20±0. 30 ,P〈0. 05 ） and SS（2. 79±2. 17 vs 1.14±0. 22 ,P〈0.01 ） levels after glucose loading were higher and that of C-peptide level（3.58±3. 10 vs 8.33±6. 99,P〈0. 01 ） was lower in diabetes group. The levels of fasting glueagon were positively correlated with that of fasting SS in two groups（ both P〈0. 01 ）. These results suggest that disturbance exists in hormones from α and δ ceils besides the dysfunction of β cells in patients with type 2 diabetes.

关 键 词：胰升糖素 生长抑素 C肽 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]