细辛对紫杉醇诱导的大鼠神经病理性疼痛的影响  

Effect of Asarum on Taxol-induced Neuropathic Pain in Rat

作　　者：郑卫红[1] 刘朝奇[2] 吕佰瑞[2] 

机构地区：[1]三峡大学医学院药理 [2]三峡大学分子生物学研究所,湖北宜昌443002

出　　处：《中国疼痛医学杂志》2011年第10期620-623,共4页Chinese Journal of Pain Medicine

基　　金：湖北省自然科学基金资助项目(2009CDZ036);湖北省教育厅科学技术研究项目(D20101208)资助课题

摘　　要：目的:研究细辛对紫杉醇诱导的神经病理性疼痛的作用,并观察其对紫杉醇抗肿瘤作用的影响,评价细辛防治化疗痛的应用价值。方法:用von Frey细丝测试大鼠机械性痛阈值;用辐射热测痛仪检测大鼠热痛阈值;用MTT法测定肺癌细胞A549的存活率,测定不同浓度细辛对紫杉醇的肺癌细胞A549生长抑制率的影响。结果:紫杉醇于给药第5天后,明显降低大鼠机械刺激痛阈值,但对大鼠热刺痛阈值无明显影响,而细辛则显著提高模型大鼠的机械刺激痛阈值与对照组比较(P<0.05)。同时,不同浓度的细辛均没有降低紫杉醇的肺癌细胞A549生长抑制率。结论:细辛对紫杉醇诱导的大鼠机械性痛觉过敏有抑制作用,且不降低其抑制肺癌细胞生长的作用,对化疗痛的防治具有积极意义。Objective： To investigate the effect of Asarum on Taxol-induced neuropathic pain and its influence on anti-tumor effect.Methods： Von Frey filament was used to detect the mechanical pain thresho-ld of rat.Radiant heat plate test was used to test thermal pain threshold of rat.MTT method was used to detect the survival rate of lung cancer cell A549.The effect of different concentration Asarum on the lung cancer cell growth inhibition rate of Taxol was observed.Results： Taxol reduced significantly the mecha-nical pain threshold,but not the thermal pain threshold of rat.Asarum increaced the mechanical pain thr-eshold of model rat（vs.control P ﹤ 0.05） and did not decreace the growth inhibition rate of Taxol in lung cancer cell A549.Conclusion： Asarum can relieve the Taxol-induced mechanical hyperalgesia in rat without reducing its cancer cell killing efficiency.This may have positive impact for the control of chemot-herapy-induced neuropathic pain.

关 键 词：细辛 化疗诱导的神经病理性疼痛 紫杉醇 

分 类 号：R285[医药卫生—中药学]