采用UPLC-Q-TOF/MS^E鉴别芪苈强心胶囊有效部位中的化学成分  

Identification of chemical constituents in Qiliqiangxin capsule by UPLC-Q-TOF/MSE

作　　者：康利平[1] 赵阳[1] 余河水[1] 刘奕训[1] 熊呈琦[1] 谭大维[1] 贾继明 王宏涛 田书彦 马百平[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]河北以岭医药研究院,河北石家庄050035

出　　处：《药学学报》2011年第10期1231-1236,共6页Acta Pharmaceutica Sinica

基　　金：国家科技支撑计划资助项目(2006BAI08B04-09);国家重点基础研究发展计划(973计划)资助项目(2005CB523301)

摘　　要：为了全面快速地阐明复方中药芪苈强心胶囊的化学组成,本文利用UPLC-Q-TOF/MSE对芪苈强心胶囊进行了快速分析和成分鉴定,从芪苈强心胶囊中鉴定了40个化合物,并归属了各化合物的单味药来源。结果显示,芪苈强心胶囊的主要成分包括三萜皂苷类、黄酮苷类、C21甾类和酚酸类等。该研究比较全面地阐明了芪苈强心胶囊的化学组成,为此中药复方制剂的质量控制和物质基础研究奠定了基础。In order to clarify the chemical constituents in Qiliqiangxin capsule,a rapid ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry（UPLC-Q-TOF/MSE） method was established.Forty peaks were identified on line using this method.The herbal sources of these peaks were assigned.The results implied that triterpenoid saponins,flavonoid glycosides,C21-steroids and phenolic acids were included in the main components of Qiliqiangxin capsule.The method is simple and rapid for elucidation of the constituents of Qiliqiangxin capsule and the results are useful for the quality control of Qiliqiangxin capsule.

关 键 词：芪苈强心胶囊 UPLC-Q-TOF/MSE 三萜皂苷 

分 类 号：R917[医药卫生—药物分析学]