不同剂量托烷司琼预防术后镇痛恶心呕吐的效果  

Effect of different doses of tropisetron in postoperative nausea and vomiting

作　　者：章杭[1] 张帆[1] 李丰[1] 

机构地区：[1]杭州市第一人民医院吴山院区麻醉科

出　　处：《中国临床药理学与治疗学》2011年第9期1057-1059,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:探讨不同剂量的托烷司琼预防术后镇痛恶心呕吐的效果。方法:将本院2005年1月至2010年12月收治的择期进行胸部手术的150例患者,随机分为A、B、C三组,每组50例。A组在镇痛泵加入5 mg托烷司琼,B组加入10 mg托烷司琼,C组采用0.9%生理盐水,比较三组患者的疗效、药物的不良反应。结果:A、B两组在防止术后恶心呕吐的疗效方面无统计学差异,但均显著优于C组(P<0.05)。A、B两组的不良反应显著多于C组(P<0.05),但均可以耐受。结论:5 mg、10 mg托烷司琼预防术后镇痛恶心呕吐的效果均较为满意,且不良反应可以耐受。AIM： To study the analgesic effect of different doses of tropisetron in preventing postoperative nausea and vomiting.METHODS： ASA grade Ⅰ-Ⅱ score of 150 cases,which was admitted for elective thoracic surgery in our hospital from January 2005 to December 2010,were divided into A,B,C three groups,n=50,A group using the analgesia adding 5 mg tropisetron,B group using the analgesia with 10 mg tropisetron,C group using 0.9% saline,compared the postoperative nausea and vomiting efficacy and adverse drug reactions of three groups of patients.RESULTS：A,B groups had no significant efficacy differences in the prevention of postoperative nausea and vomiting,but were significantly better than C group,P0.05.The adverse reactions of A,B groups were significantly more than C Group,P0.05,but can be tolerated.P0.05.A,B groups of adverse reactions was significantly more than Group C,P0.05,but can be tolerated.CONCLUSION： The analgesic effects in preventing postoperative nausea and vomiting of 5 mg,10 mg tropisetron are more satisfied,and adverse reactions can be tolerated.

关 键 词：术后恶心呕吐 托烷司琼 

分 类 号：R614.1[医药卫生—麻醉学]