采用小波分析的方法提取MRS中与肌酸重叠的小信号γ-氨基丁酸  

Applying wavelet transformation to obtain GABA in MR spectroscopy

作　　者：王成[1] 全红[1] 杨志勇[1] 吕粟[2] 吴杞柱[2] 龚启勇[2] 

机构地区：[1]武汉大学物理科学与技术学院,湖北武汉430072 [2]四川大学华西医院磁共振研究中心,四川成都610000

出　　处：《中国医学影像技术》2011年第10期2131-2135,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(10875092)

摘　　要：γ-氨基丁酸(GABA)是人体中重要的抑制性神经递质,但其浓度很难在体测量。本文采用小波分析方法对1H-MRS波谱数据进行分析处理,通过抑制肌酸(Cr)信号来提取GABA峰:首先分析5名正常成年人普通PRESS序列扫描的数据(共15组),其中12组出现GABA峰;然后将此方法与J-difference edited脉冲序列对4名未成年人的扫描结果进行对比;最后处理2只正常恒河猴与致其癫痫后的脑部MRS数据。3个步骤的处理均得到比较满意的结果,成功提取出了与Cr重叠的GABA峰(3.00 ppm)。The γ-Aminobutyric acid（GABA） is an important catastaltic neurotransmitter in human body,but its concentration is difficult to be measured in vivo.In this paper,wavelet transformation was used to extract GABA by suppressing creatine（Cr） in analyzing 1H-MRS data： First 15 groups of data set of 5 healthy people scanned with PRESS sequence were analyzed,and GABA was detected in 12 of them.Then the results of the proposed method were compared with those of J-difference edited sequence obtained by 4 minors.At last,MRS data in 2 healthy monkey head and epileptic monkey head were analyzed.All processes were successful to obtain GABA that overlapped with Cr in 3.00 ppm.

关 键 词：Γ-氨基丁酸 质子磁共振波谱 小波分析 

分 类 号：R445.2[医药卫生—影像医学与核医学]