H5N1亚型高致病性禽流感病毒对鸽的致病性分析  

Pathogenicity of H5N1 Highly Pathogenic Avian Influenza Virus in Pigeons

作　　者：乔立旺[1] 焦培荣[1] 张东霞[1] 李芳[1] 胡自立[1] 刘海玲[1] 辛朝安[1] 廖明[1] 罗开健[1] 

机构地区：[1]华南农业大学兽医学院农业部动物疫病防控重点开放实验室,广东省动物源性人兽共患病预防与控制重点实验室,广东广州510642

出　　处：《动物医学进展》2011年第10期15-18,共4页Progress In Veterinary Medicine

基　　金：教育部创新团队项目(IRT0723);国家肉鸡产业技术体系项目(nycytx-42-G3-03);广东省自然科学基金项目(10151064201000021,10251064201000004);广东省科技计划项目(2010B020307005)

摘　　要：为评估H5N1亚型禽流感病毒对鸽的致病性,用我国2004年分离的一株H5N1亚型禽流感病毒A/pigeon/GD/C2/2004(H5N1)人工感染4周龄鸽,进行了致病性试验。结果表明,该株病毒以106EID50/100μL剂量感染能致死鸽,致死率为22.2%,病毒能在感染鸽体内广泛分布,其中肺脏和肾脏中病毒含量达到104.50EID50/mL,表明该株病毒对鸽具有感染性,且感染鸽未通过喉头和泄殖腔向外排毒。To evaluate the pathogenicity of H5N1 subtype Avian influenza viruse（AIV） in pigeons,4-week-old pigeons were infected artificially with A/pigeon/GD/C2/2004（H5N1） which isolated from China in 2004.The results showed that the pigeons could be killed with 106EID50/100 μL dose of virus and the lethality was 22.2%.The virus could be isolated from nearly all organs of the infected pigeons,especially in the lung and the kidney reaching titers of 104.50EID50/mL.The result showed H5N1 AIV had the pathogenicity to pigeons.Besides,we found that all the infected pigeons have not shed virus via the oropharynx and the cloaca.

关 键 词：禽流感病毒 H5N1 鸽 感染 

分 类 号：S852.659[农业科学—基础兽医学]