凝血因子Ⅶ5'F7基因多态性与冠心病的相关性研究  

Relationship between 5'F7 gene Polymorphism of Coagulation Factor Ⅶ and Coronary Heart Disease

作　　者：魏涛[1] 孙雪荣[2] 陈艳萍[2] 

机构地区：[1]青岛市市立医院,山东青岛266012 [2]青岛市妇女儿童医疗保健中心,山东青岛266012

出　　处：《现代生物医学进展》2011年第20期3916-3918,3896,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨凝血因子Ⅶ基因5'F7多态性与中国汉族人冠心病的关系。方法:利用聚合酶链反应-限制性片段长度多态性方法测定43例健康人(正常对照组)和116例冠心病患者5'F7多态性,确定其基因型;统计分析其与冠心病的关系及与冠状动脉狭窄程度的相关性。结果:CHD组与对照组之间5'F7多态性的基因型P0P0与(P0P10+P10P10)频率分布差异总体比较有统计学意义(X2=2.416,P<0.05),P0、P10等位基因在两组间的频率分布总体差异有统计学意义(X2=2.302,P<0.05)。结论:FⅦ基因5'F7多态性中P10等位基因可能是CHD的遗传保护因子,但与其病变支数无关。Objective： To investigate the relationship between polymorphism of Coagulation Factor Ⅶ and coronary artery disease. Methods： Polyrnerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was adopted to study the 5＇F7 polymorphism of Coagulation Factor Ⅶof controls （43） and patients （116）; the correlation between the CHD and 5＇F7 polymorphism. Results：There was a significant difference in the frequency distribution of P0P0 and （POP 10＋P 10P 10 ）of 5＇F7 polyrnorphism between the cases of control group and CHD patients （X2=-2.416,P〈0.05）;There was a statistical significance in the frequencies distributional difference in the allelomorphic gene P0 and P10 between the two groups（X2=-2.302 ,P〈0.05 ）. Conclusion： The allelomorphic gene P10 of 5＇F7 polymorphism is possible geno-protective factor of CHD,but it is not related with number of pathological changed coronary artery. Key words：

关 键 词：冠状动脉 凝血因子Ⅶ 基因多态性 

分 类 号：R711.75[医药卫生—妇产科学]