生物节律影响巨核细胞发育和血小板产生的研究进展  

Effects of Biological Rhythm on Megakaryocyte Development and Platelet Formation

作　　者：赵越[1] 张建法[1] 

机构地区：[1]南京理工大学分子代谢中心,江苏南京210094

出　　处：《现代生物医学进展》2011年第20期3958-3960,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金重大项目(30730030)

摘　　要：自然界中生物体的生命活动、生活习性都存在着一定的周期性变化。生物昼夜节律的产生是以内源性的生物钟系统为基础的。生物钟不仅易受到外界环境的影响,而且可以通过调控一系列特定的下游基因的表达,影响生物体的生理生化过程。巨核细胞是生成血小板的前体细胞,经过分化、增殖、成熟和裂解,最终生成血小板。血小板是一种没有细胞核的特殊细胞,在生理性止血和器官修复上发挥着重要作用,同时参与血栓等多种疾病的发生。近几年借助现代分子生物学和细胞生物学手段,证实了哺乳动物的巨核细胞和血小板的生成呈现明显的周期性的变化,利用生物钟基因缺失模型进一步发现了生物钟基因对巨核细胞和血小板的影响。本文概述了生物节律对巨核细胞和血小板的影响,为进一步研究巨核细胞的发育和血小板生成机制提供了参考。The activity and habit of organisms in nature exhibit circadian rhythms. The circadian rhythms in physiology and behavior are controlled by internal circadian clock. The circadian clock is composed of several genes by transcription/translation-based feedback loop. The circadian clock is not only affected by external environment, but also can regulate several downstream genes expression, thus affecting the organism＇s physiological and biochemical processes. Megakaryocytes are precursor cells of platelet, which generate platelets after differentiation, proliferation, maturation and fragmentation. Platelets are anucleate cells which play essential roles in hemostasis and organ repair, participate in thrombosis and various diseases. In recent years, megakarycoytes and platelet formation show significant circadian changes, and clock gene can affect megakaryocytes and platelet formation using gene knock-out animal models. This article reviews the recent progress in the influence of circadian clock on megakarycytes and platelet, and provides evidences to further understand the megakaryocyte development and the mechanism ofplatelet formation.

关 键 词：生物节律 巨核细胞 血小板 

分 类 号：R331.143[医药卫生—人体生理学]