孤独症患儿头围测量分析  

Head circumference measurements in children with autism

作　　者：谭迎花[1] 郗春艳[1] 汪永娟[1] 王丽波[1] 韩晶晶[1] 

机构地区：[1]中国医科大学附属盛京医院发育儿科,沈阳110004

出　　处：《中国实用儿科杂志》2011年第10期760-762,共3页Chinese Journal of Practical Pediatrics

基　　金：国家自然科学基金资助项目(30872802);辽宁省教育厅课题(2008816)

摘　　要：目的探讨孤独症患儿头围发育情况。方法研究对象为中国医科大学附属盛京医院2009年9月至2011年6月确诊的孤独症患儿(孤独症组)156例,其中≤3岁74例,>3岁82例。同时选择健康儿童141名作为正常对照组,其中≤3岁58名,>3岁83名。分别测量两组头围并进行组间比较。结果孤独症组≤3岁患儿头围平均值与大头所占比例均大于正常对照组,两组差异有统计学意义(P<0.05)。孤独症组>3岁患儿头围平均值与大头所占比例与健康儿童基本相似,两组差异无统计学意义(P>0.05)。在除外大头患儿后,两组头围平均值比较差异无统计学意义(P>0.05)。结论孤独症患儿生后早期头围偏大,并且常伴大头,头围异常也是患儿重要的临床特征之一。了解孤独症头围发育可为孤独症的发病机制提供参考依据。Objective To assess the head circumference in children with autism. Methods One hundred and fifty-six children with autism （74 children ≤3 years and 82 children 〉 3 years, respectively） and 141 well-matched healthy controls （58 children ≤3 years and 83 children 〉 3 years, respectively） were investigated by measuring the head circumference. Results The autistic children demonstrated significantly higher head circumference than the c.ontrol children in the ≤3 years group （P 〈 0.05）.Compared to the healthy controls, the autistic individuals also manifested more macrocephalus （P 〈 0.05）. However, when the children who displayed macrocephalus were excluded, there was no significant difference in the head circumference between the two groups. Conclusion Head circumference abnormalities are a common feature of autistic patients and may provide some clues to the pathogenesis of autism.

关 键 词：孤独症 头围 大头 

分 类 号：R72[医药卫生—儿科]