不同方法静脉注射甘露醇对兔耳缘静脉及其周围组织的影响研究  

Effects of Different Intravenous Injection Methods of Mannitol on Rabbit Ear Vein and Its Surrounding Tissue

作　　者：何春渝[1,2] 胡丽君[1] 

机构地区：[1]重庆医科大学附属儿童医院普外科,重庆市400014 [2]成都医学院护理学院护理教研室,成都市610083

出　　处：《中国药房》2011年第41期3870-3872,共3页China Pharmacy

摘　　要：目的:比较前导后冲法和常规法静脉注射甘露醇对兔耳缘静脉及其周围组织的影响,为临床给药提供参考。方法:将家兔随机分为实验组和对照组,每组15只,实验组采用前导后冲法静脉注射甘露醇,对照组用常规法静脉注射甘露醇,注射部位为兔耳缘静脉,给药24h后,光镜观察2组兔耳缘静脉及其周围组织血管壁损伤、血管周围出血、血管淤血、炎细胞浸润及纤维组织增生等情况。结果:与对照组比较,实验组兔耳缘静脉及其周围组织血管壁损伤、血管周围出血、血管淤血、炎细胞浸润均明显减轻(P<0.05或P<0.01),纤维组织增生无明显差异。结论:与常规法比较,前导后冲法能明显减轻静脉注射甘露醇对实验动物静脉及其周围组织的损伤,建议临床推广使用。OBJECTIVE： To compare the influence of before and after the intravenous infusion vs. routine intravenous injection of mannitol on the rabbit ears vein and its surrounding tissue, and to provide reference for clinical drug use. METHODS： Rabbits were randomly divided into experimental group and control group with 15 rabbits in each group. The experimental group was given mannitol with method of before and after the intravenous infusion, while control group was given mannitol with routine intravenous injection via ear vein. After 24 hours, light microscope was used to observe damage of vessel wall, perivascular hemorrhage, congestion, inflammatory infiltration and proliferation of fibrous tissue. RESULTS： Compared with control group, the damage of vessel wall, perivascular hemorrhage, congestion, inflammatory infiltration of experimental group relieved significantly （P〈0.05 or P〈0.01）, while proliferation of fibrous tissue had no significant difference. CONCLUSION： Compared with routine method, be- fore and after the intravenous infusion can relieve injury of vein and its surrounding tissue induced by intravenous injection of mannitol, and it is suggested to be spreading in the clinic.

关 键 词：甘露醇 前导后冲法 常规法 静脉注射 静脉 周围组织 损伤 

分 类 号：R965[医药卫生—药理学]