pH值对吲哚美辛芳基吗啉酯衍生物表观油水分配系数的影响  

Effect of pH on Apparent Oil/Water Partition Coefficient of Prodrugs of Indomethacin

作　　者：凌伟[1,2] 唐静怡[2] 石磊[3] 戴智勇[1] 徐智[1] 

机构地区：[1]中南大学湘雅医院,长沙410008 [2]中南大学药学院,长沙410013 [3]湖南大学化学化工学院,长沙410082

出　　处：《中国现代应用药学》2011年第10期903-906,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的测定盐酸吲哚美辛芳基吗啉酯衍生物的表观油水分配系数并探讨pH值和结构改造对其的影响。方法用摇瓶法测定盐酸吲哚美辛芳基吗啉酯衍生物在正辛醇缓冲液体系中的表观油水分配系数,建立紫外分光光度法测定其含量。结果 25℃时盐酸吲哚美辛芳基吗啉酯衍生物在pH为4时其表观油水分配系数最大。结论盐酸吲哚美辛芳基吗啉酯衍生物的表观油水分配系数与介质的pH和结构改造中引入基团的极性等因素有关。OBJECTIVE To study the effect of pH on apparent oil/water partition coefficient of prodrugs of indomethacin.METHODS The apparent oil/water partition coefficient of prodrugs of indomethacin was measured by shaking flask method.The concentration of prodrugs of indomethacin was determined by UV.RESULTS When the temperature was 25 ℃,the prodrugs of indomethacin have the highest partition coefficients in n-octanol/pH 4 buffer solution system.CONCLUSION The apparent oil/water partition coefficients of prodrugs of indomethacin are correlated to pH of the medium and the polarity of group which is added.

关 键 词：盐酸吲哚美辛芳基吗啉酯衍生物 表观油水分配系数 酸碱度 引入基团 

分 类 号：R927.14[医药卫生—药学]