暖心胶囊对心衰大鼠肌浆网Ca^(2+)-ATP酶、血浆AngⅡ、ALD以及血流动力学的影响  

Effect of Nuanxin Capsule on Sarcoplasmic Reticulum Ca^(2+)-ATPase,Plasma Angiotensin Ⅱ and Aldosterone,and Hemodynamic Parameters in Heart Failure Rats

作　　者：邹旭[1] 牛平平[2] 姚耿圳[2] 潘光明[1] 

机构地区：[1]广东省中医院心脏中心,广东广州510120 [2]广州中医药大学,广东广州510405

出　　处：《新中医》2011年第11期110-112,共3页New Chinese Medicine

基　　金：广东省财政厅资助项目(编号:粤财工[2009]432号)

摘　　要：目的:观察暖心胶囊对心衰大鼠心肌肌浆网Ca2+-ATP酶、血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)以及血流动力学的影响。方法:将91只雄性SD大鼠随机分为正常对照组,阿霉素(ADR)心衰模型组,暖心胶囊低、中、高剂量组,卡托普利组以及心宝丸组,每组13只,腹腔注射ADR建立心衰大鼠模型,分别给予相应药物灌胃观察6周,行Ca2+-ATP酶、血浆AngⅡ、血浆ALD以及血流动力学检测。结果:暖心胶囊中、高剂量组可改善ADR心衰大鼠心脏的收缩和舒张功能,提高Ca2+-ATP酶活性,降低血浆AngⅡ、ALD含量(P<0.05,P<0.01)。结论:暖心胶囊可以对抗ADR心衰大鼠心功能的下降,其机制可能与提高Ca2+-ATP酶活性,下调血浆AngⅡ、ALD含量有关。Objective： To study the effect of Nuanxin Capsule （NC） on sarcoplasmic reticulum Ca2＋-ATPase, plasma angiotensin Ⅱ （Ang Ⅱ） and aldosterone （ALD）, hemodynamic parameters in heart failure rats. Methods： SD rat models of heart failure rats were established by intraperitoneal injection of adriamycin（ARD）. Rats were randomly divided into 7 groups： normal control group, ARD group, low-, moderate- and high-dose NC groups, captopril group and Xinbao Pills group, 13 rats in each group. After 6 weeks, hemodynamic parameters were detected, Ca2＋-ATPase activity was measured, and the plasma concentrations of Ang II and ALD were determined. Results： The systolic and diastolic function in ADR-induced heart failure rats was improved, the activities of Ca2＋-ATPase were increased, and the plasma concentrations of Ang II and ALD were reduced in moderate- and high-dose NC groups（P 〈 0.05 or P 〈 0.01）. Conclusion： Nuanxin Capsule can counteract the impairment of heart function in ADR-induced heart failure rats, and its possible mechanism is related with the increase of activities of Ca2＋-ATPase and the decrease of the plasma concentrations of Ang II and ALD.

关 键 词：暖心胶囊 心力衰竭 肌浆网Ca2+-ATP酶 血浆血管紧张素Ⅱ 醛固酮 动物实验 大鼠 

分 类 号：R285.5[医药卫生—中药学]