黄连解毒汤的药动学-药效学相关性研究  

Analysis on pharmacokinetics-pharmacodynamics correlation of Huanglian Jiedu Decoction

作　　者：宋珏[1] 路通[2] 谢林[3] 刘晓东[3] 

机构地区：[1]安徽医科大学药学院,安徽合肥230032 [2]中国科学院上海药物研究所药物代谢研究中心,上海201203 [3]中国药科大学江苏省药物代谢动力学重点实验室,江苏南京210038

出　　处：《中草药》2011年第10期2042-2046,共5页Chinese Traditional and Herbal Drugs

基　　金：安徽省高等学校青年教师科研资助计划(2006jq1106);安徽医科大学校科研基金(2006kj19)

摘　　要：目的研究大鼠给予黄连解毒汤(HJD)、黄芩提取物及黄芩苷后,血清中黄芩苷和汉黄芩苷的经时变化及抗氧化作用的药动学-药效学(PK-PD)相关性。方法以HPLC法同步监测血清黄芩苷、汉黄芩苷的水平,求算其血药浓度-时间曲线下面积(AUC),并将含药血清抗氧化作用的效应-时间曲线下面积(AUE)与对应的AUC进行相关性分析。结果 HJD、黄芩提取物及黄芩苷的lgAUC-AUE均呈近似"S"形曲线。结论 HJD、黄芩提取物及黄芩苷的抗氧化作用与血清黄芩苷、汉黄芩苷水平呈正相关,黄芩苷可能是HJD及黄芩抗氧化作用的活性成分,汉黄芩苷也有一定的抗氧化作用。Objective To study pharmacokinetics-pharmacodynamics（PK-PD） correlation of Huanglian Jiedu Decoction（HJD） through simultaneous determination of baicalin and wogonoside in serum after oral administration of HJD,Scutellariae Radix extract,and baicalin to rats.Methods The serum concentrations of baicalin and wogonoside were simultaneously detected with an HPLC method and the area under serum concentration-time curve（AUC） was calculated.The correlation between the parameter area under serum effect-time curve（AUE） and AUC was analyzed.Results The scatterplots of lg（AUC）-AUE in above three groups were formed as ＂S-shaped＂ curves.Conclusion The anti-oxidative effects of HJD,Scutellariae Radix extract,and baicalin have a positive correlation with baicalin and wogonoside levels in serum.Baicalin may act as one of the anti-oxidants both in Scutellariae Radix extract and HJD.Also,wogonoside has anti-oxidative effects to some extent.

关 键 词：黄连解毒汤 黄芩 黄芩苷 汉黄芩苷 药动学 药效学 

分 类 号：R285.5[医药卫生—中药学]