复方尼阿措提取物对高脂血症大鼠的调血脂作用  

Lipid-regulating effect of compound Ni A-Cuo extract

作　　者：李运[1] 段博文[1] 卫阳飞[1] 宋家玲[1] 赵小芳[1] 李建银[1] 杨永建[1] 

机构地区：[1]兰州大学药学院,兰州730000

出　　处：《中国新药杂志》2011年第20期2022-2025,共4页Chinese Journal of New Drugs

基　　金：甘肃省科技支撑计划(0804NKCA120);甘肃省中医药管理局(GZK-2010-18)

摘　　要：目的:探讨复方尼阿措提取物(CNAE)的调血脂作用。方法:通过灌胃脂肪乳剂制备实验性高脂血症大鼠模型。随机分为正常对照组、模型对照组、阳性对照组(1 mL.kg-1)、柳茶水提物(SAE)低、高剂量组(6.01,2.0 g.kg-1)、CNAE低、高剂量组(8.0,16.0 g.kg-1)。除正常组外,各给药组大鼠灌胃给予脂肪乳剂,基础饲料喂养,末次给药后,腹主动脉采血测定血清总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和丙二醛(MDA)的含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性。结果:CNAE能明显降低TC、TG、LDL-C和MDA含量(P<0.01),升高HDL-C浓度,显著提高SOD及GSH-Px酶活性(P<0.01),且降血脂作用优于SAE。结论:CNAE具有明显的调血脂和抗氧化作用,提示其可用于高脂血症的防治。Objective： To investigate the lipid-regulating effect of compound Ni A-Cuo extract（CNAE）.Methods： Hyperlipidemia was induced by intragastric administration of lipid emulsion in rats.The rats were randomly divided into 7 groups,and treated with CNAE（8.0 and 16.0g·kg-1）,SAE（6.0 and 12.0g·kg-1）,or a positive control agent（1mL·kg-1）.Except control group,rats in other groups were fed with lipid emulsion in addition to basal feed.The blood was collected from the aorta abdominalis of rats for measuring the serum TC,TG,LDL-C,HDL-C,MDA,SOD and GSH-Px.Results： CNAE significantly decreased the serum contents of TC,TG,LDL-C and MDA（P0.01）;markedly increased serum level of HDL-C,and serum activities of SOD and GSH-Px in hyperlipidemic rats.The lipid-reducing effect of CNAE was more potent than that of SAE.Conclusion： CNAE possesses obvious lipid-regulating and antioxidative effects,suggesting a significance to prevent and/or treat hyperlipidemia.

关 键 词：复方尼阿措 高脂血症 血脂调节作用 抗氧化 

分 类 号：R972.6[医药卫生—药品]