国产及进口丙泊酚在无痛人工流产麻醉中的效价比  

Potency ratio of domestic and imported propofol in anesthesia of painless artificial abortion

作　　者：赵素贞[1] 刘月强[1] 杨五臣[1] 童明军[1] 侯铁柱[1] 张春雷[1] 

机构地区：[1]河南省人民医院内镜中心,郑州450003

出　　处：《中国实用医刊》2011年第20期8-10,共3页Chinese Journal of Practical Medicine

摘　　要：目的评价国产和进15／丙泊酚（力蒙彬得普利麻）的临床麻醉效果及市场价格差异。方法拟行无痛人工流产患者60例，将其随机分为两组，力蒙欣组（L组）和得普利麻组（D组），每组30例。入室患者开放上肢静脉，静脉注射舒芬太尼0．1μg/kg后，靶控输注丙泊酚血浆浓度4μg／ml。L组输注1％力蒙欣（批号：0908281西安力邦生物制药有限公司），D组输注1％得普利麻（批号：GG244AstraZeneca公司意大利）。警觉与镇静评分（OAA／S）评分≤1，脑电双频指数（BIS）〈60时开始手术，术中维持BIS40—60。术中连续监测血压（Bp）、心电图（ECG）、脉搏血氧饱和度（SpO：）和BIS，每60秒对患者进行OAA／S，记录手术时间、丙泊酚用量、丙泊酚靶控输注时间、麻醉起效时间、唤醒时间和唤醒时BIS值、指令反应时间、BIS〉70、术中知晓、遗忘和各种并发症及不良反应。结果与麻醉前比较，注药后1min时和手术开始时两组平均血压（MBp）下降（P〈0．05），心率（HR）呈下降趋势。BIS明显下降（P〈0．05）并持续至术毕，清醒后回升，但仍低于基础值。BIS和血压变化两组间比较差异无统计学意义（P〉0．05）。两组手术时间，丙泊酚用量，麻醉用药时间、麻醉起效时间、唤醒时间和唤醒时BIS值、指令反应时间和BIS〉70比较差异无统计学意义（P〉0．05）。两组患者麻醉效果评级及注射病情况比较差异无统计学意义（P〉0．05），D组呼吸抑制（6／2例）和呼吸暂停（6／1例）发生率高于L组，D组出现术后遗忘1例。进口丙泊酚的药价是国产丙泊酚的1．2倍。结论力蒙欣和得普利麻用于短时快通道麻醉（无痛人工流产术），麻醉效果和安全性差异无统计学意义，力蒙欣的效一价比优于得普利麻。Objective To evaluate the clinical anesthesia effects and market price distinction between domestic propofol and imported propofol （ Limengxin / Diprivan）. Methods Sixty patients un- dergoing painless artificial abortion were randomly divided into two groups： Limengxin group （group L） and Diprivan group （group D） ,30 cases for each group. The two groups received intravenous infusion of sufentanil at 0. 1 μg/kg. The patients received propofol （group L： 1% Limengxin and group D： 1% Diprivan） by target controlled infusion （TCI） at a target effect site concentration（Ce） of 4 μg/ml. The surgery began when BIS 〈 60, and it was needed to maintain BIS 40 -60. During the operations, Bp, ECG, SpO2 and BIS were continuously monitored. OAA/S was made to patients every 60 seconds, and op- eration time, propofol dosage, propofol TCI time, onset time, arousal time and arousal BIS value, instructions response time, BIS 〉 70 time, awareness in operation, amnesia, various complications and adverse effects were recorded. Results The mBP was decreased after anesthesia in both groups at 1 minute after the start of propofol TCI and when the operations began. The HR presented decrease tendency. BIS was significantly decreased （ P 〈 0. 05 ） until to the operations ended, and it was increased after the patients awaked, but it was lower than that before anesthesia. There were no significant difference in BIS and BP between the two groups （P 〉 0.05 ）. There were no significant difference in operation time, propofol dos- age, medication time, onset time, arousal time and arousal BIS value, instructions response time, BIS 〉 70 time between the two groups （P 〉 0.05）. There were also no significant difference in the rank of anes- thesia effects and the respiratory depression state of infusion pains between the two groups （P 〉 0.05）. The incidence rate of （6：2） and breathing holding （6：1） in group D was higher than that in group L.There was one patient who had postoperati

关 键 词：药物释放系统 丙泊酚 脑电描记术 人工流产 

分 类 号：R169.4[医药卫生—公共卫生与预防医学]