乌司他丁对氟尿嘧啶植入剂治疗肝癌手术后恶性胸腹水患者免疫功能的影响观察  

The effects of Ulinastatin on malignant pleural/ascitic effusion patients with fluorouracil implant treatment after resection of hepatocellular carcinoma

作　　者：吕永丰[1] 陈清霞[1] 李国成[1] 刘纯霞[1] 

机构地区：[1]中山大学孙逸仙纪念医院,广东广州510120

出　　处：《成都医学院学报》2011年第3期254-256,共3页Journal of Chengdu Medical College

摘　　要：目的观察乌司他丁对使用中人氟安(植入用缓释氟尿嘧啶,5-Fu)的肝癌手术后恶性胸腹水患者治疗前后免疫功能的影响。方法 80例肝癌手术后恶性腹水患者,以氟尿嘧啶植入剂1500mg植入胸腔、腹腔治疗。其中乌司他丁组40例,治疗期间按5000U/kg连续加用乌司他丁14d治疗,40例患者作为对照组。采用流式细胞术检测治疗前后外周血T细胞亚群及NK细胞的水平。结果治疗后7d,乌司他丁组CD4+、CD8+细胞计数及NK细胞水平明显优于对照组(P<0.05),治疗后14d,乌司他丁组CD4+、CD8+细胞计数及NK细胞水平仍明显优于对照组(P<0.05)。结论乌司他丁在中人氟安治疗肝癌手术后恶性腹水患者时能有效增强机体的免疫功能。Objective To observe the effects of Ulinastatin（UTI）on immunity of malignant pleural/ascitic effusion patients who were treated with fluorouracil sustained release for implant（slow-release fluorouracil,5-Fu） after resection of hepatocellular carcinoma.Methods 80 patients with malignant pleural/ascitic effusion after resection of hepatocellular carcinoma were treated with fluorouracil sustained release for implant at a fixed dosage of 1500 mg.40 of them were co-administed with Ulinastatin 5000 U / kg up to continuous 14 days（UTI group）,40 of them were recruited as control group.The detection of peripheral T lymphocyte subsets and NK cells before and after treatment at different periods were performed with flow cytometry.Results The CD4＋,CD8＋ cells counts and NK cells level of UTI group were significantly higher than those of control group after 7 days treatment and 14 days treatment.Conclusion Ulinastatin could effectively enhance the immunity of malignant pleural effusion patients with Fluorouracil implant treatment after resection of hepatocellular carcinoma.

关 键 词：氟尿嘧啶缓释制剂 乌司他丁 免疫功能 恶性胸腔积液 恶性腹腔积液 

分 类 号：R969[医药卫生—药理学]