肾病综合征患者血浆细菌内毒素及(1,3)-β-D-葡聚糖定量检测与临床意义  

The clinical significance and quantitative detection of plasma bacterial endotoxin and(1,3)-β-D-glucan for patients with nephrotic syndrome

作　　者：周碧燕[1] 李友邕[1] 覃李线[1] 陈丽华[1] 

机构地区：[1]南宁市第一人民医院,广西南宁530021

出　　处：《中国医药导报》2011年第30期27-28,共2页China Medical Herald

摘　　要：目的:研究肾病综合征患者检测血浆中细菌内毒素和(1,3)-β-D-葡聚糖的临床意义。方法:选择2009年2月～2011年2月住院的肾病综合征患者42例,检测患者血浆中的细菌内毒素,并分析其与肌酐及尿素的相关性,分析(1,3)-β-D-葡聚糖对于肾病综合征患者真菌感染诊断的敏感性和特异性。结果:内毒素与尿素及肌酐均具有明显的正相关性(r=0.928,P<0.01;r=0.989,P<0.01)。随着内毒素的升高,肾功能逐渐下降,(1,3)-β-D-葡聚糖对于肾病综合征患者真菌感染诊断的敏感性和特异性分别为83.33%、93.75%,远远高于其他两种诊断方法。结论:肾病综合征患者(1,3)-β-D-葡聚糖和细菌内毒素的检测对改善患者预后,降低死亡率具有重要的临床意义。Objective：To study the clinical significance of the detection of plasma bacterial endotoxin and（1,3）-β-D-glucan for patients with nephrotic syndrome.Methods：42 patients with nephrotic syndrome in our hospital from February 2009 to February 2011 were selected.Plasma bacterial endotoxin were detected and its correlation with serum creatinine and urea were analyzed.The sensitivity and specificity of（1,3）-β-D-glucan for the diagnosis of fungal infection of patients with nephrotic syndrome were analyzed.Results：The endotoxin had obvious positive correlation with urea and creatinine（r=0.928,P〈0.01;r=0.989,P〈0.01）.The sensitiity and specificity of（1,3）-β-D-glucan in patients with nephrotic syndrome for the diagnosis of fungal infection were 93.75%,83.33% respectively,far higher than the other two kinds of diagnostic methods.Conclusion：The detection of（1,3）-β-D-glucan and bacterial endotoxin in patients with nephrotic syndrome can improve the prognosis and reduce mortality.

关 键 词：肾病综合征 内毒素 (1 3)-β-D-葡聚糖 

分 类 号：R692.6[医药卫生—泌尿科学]