肺癌化疗后贫血RDW与MCV变化的临床分析  

Change of RDW and MCV of Patients with Lung Cancer with Anemia after the Chemotherapy

作　　者：陈云兰[1,2] 赵金奇[1,2] 

机构地区：[1]昆明医学院第三附属医院 [2]云南省肿瘤医院干疗科,云南昆明650118

出　　处：《中国现代医生》2011年第29期132-133,共2页China Modern Doctor

摘　　要：目的探讨肺癌化疗后贫血患者化疗前后红细胞体积分布宽度(red blood cell volume distribution width,RDW)与平均红细胞体积(meam corpuscular volume,MCV)值的变化及临床意义。方法通过采手指末梢血检测血细胞,分析138例含铂方案化疗肺癌患者发生贫血后MCV与RDM变化。结果 138例患者经2周期以上化疗后出现不同程度的贫血,发生率为83.64%,RBC化疗前4.42±0.45,化疗后3.25±0.43,差异有统计学意义(t=14.06,P<0.01);HGB化疗前139.42±13.31,化疗后101.96±11.28,差异有统计学意义(t=15.924,P<0.01);MCV化疗前92.94±7.36,化疗后95.15±6.06,差异无统计学意义(t=1.714,P>0.05);RDW化疗前40.46±3.65,化疗后53.15±6.96,差异有统计学意义(t=11.98,P<0.01)。结论本组研究中肺癌患者行2周期以上含铂方案化疗后贫血RDW明显升高,MCV正常,属于正细胞不均一性贫血,说明肺癌患者化疗后贫血RDW的升高与含铂方案的化疗有关,其贫血原因是多方面的。Objective To explore the changes and its clinical significance of red blood cell volume distribution width （ RDW ） and meam corpuscular volume （MCV） of Lung cancer with anemia patients before and after chemotherapy. Methods Through extract Finger endings blood testing blood cells, the data of 138 cases of lung cancer patients platinum-based regime chemotherapy after with anemia were analyzed , MCV and RDW happened changes Results All 138 cases after chemotherapy appeard different degree of anemia, with an incidence of 83.64%,compare RDW： before Chemotherapy 40.46 ± 3.65, after chemotherapy 53.15 ± 6.96,with a statistically significant （ t=1 1.98, P 〈 0.01 ）. MCV： before chemotherapy 92.94 ± 7.36; after chemotherapy 95.15 ±. 6.06, there was no statistically significant （ t=1.714, P 〉 0.05 ）. Conclusion This study of patients with lung cancer line 2 cycle above platinum-based regime increased significantly after chemotherapy anemia RDW MCV normal, belongs to the positive cells sizes anemia. After that patients with lung cancer chemotherapy RDW increases and anemia of platinum-based regime, the anemia is caused by many factors.

关 键 词：肺癌 化疗 贫血 红细胞分布宽度 

分 类 号：R446[医药卫生—诊断学]