新型呋喃基Schiff碱衍生物的合成、结构和生物活性  

Synthesis,Structure and Biological Activities of Novel Furanosyl Schiff Base Derivatives

作　　者：严琳[1] 刘丰五[2] 刘宏民[2] 

机构地区：[1]河南大学化学生物学研究所,开封475004 [2]郑州大学新药研究开发中心,郑州450001

出　　处：《有机化学》2011年第10期1639-1642,共4页Chinese Journal of Organic Chemistry

基　　金：河南省科技厅科技发展计划(No.112300410179)资助项目

摘　　要：席夫碱类化合物具有独特的抗癌、抗菌、抗病毒等生物活性.以多羟烷基呋喃化合物为原料经氧化、脱水得到α,β-不饱和醛,活泼的醛羰基进一步与苯胺类化合物缩合得到8个新的呋喃基Schiff碱化合物,并对合成的化合物进行了初步的生物活性测试.Schiff base compounds have significant antitumor,antimicrobial and antiviral activities.In this study,some new α,β-unsaturated aldehydes were synthesized through oxidation and dehydration reaction.Then a series of furanosyl Schiff base derivatives were synthesized by condensation reaction of α,β-unsaturated aldehydes with various phenylamines.The preliminary biological activities of these furano-syl Schiff base derivatives were also investigated.

关 键 词：呋喃基Schiff碱衍生物 合成 晶体结构 生物活性 

分 类 号：O626.11[理学—有机化学]