80例脓毒血症患者血清降钙素原监测和预后评估的临床研究  

The Clinical Application and prognoss of Serum Procalcitonin in Sepsis

作　　者：熊明洁[1] 范红[2] 郭靓[2] 

机构地区：[1]西南大学医院内科,重庆400715 [2]四川大学华西医院实验医学科,成都610041

出　　处：《重庆医学》2011年第30期3076-3078,共3页Chongqing medicine

摘　　要：目的探讨血清降钙素原(PCT)在脓毒血症患者病情监测和预后评估的临床意义及指导临床抗菌药物的应用。方法选取脓毒血症患者80例为病例组,非脓毒血症20例为对照组,采用酶联免疫荧光法检测血清PCT水平,采用速率散射比浊法测定血清C-反应蛋白(CRP)水平。结果在脓毒血症分级中,血清PCT在感染性休克时明显升高,急性生理与慢性健康(APACH-Ⅱ)评分略有上升,差异有统计学意义(P<0.05),CRP无明显变化,差异无统计学意义(P>0.05);血清PCT值随病情加重而升高、病情缓解而降低,差异有统计学意义(P<0.05),CRP无明显变化,差异无统计学意义。结论血清PCT值与脓毒血症严重程度分级及病情转归有相关性,可用于危重患者的病情监测和预后评估。Objective To explore the clinical value of serum PCT in diagnosis and prognosis assessment of bacteria caused sepsis. Methods A total of 80 inpatients admitted to our hospital for bacteria or fungi caused sepsis were selected. Another 20 cases of non-septic infections were chosen as controls. Fast venous blood samples were collected from each septic subject in the morning before breakfast on the 1st, 3rd, 5th days, and from non-septic subjects only on the first day. Enzyme linked fluorescent assay （ELFA） was employed to measure the serum PCT. CRP was determined by immunity-turidity method. Results Serum PCT level was much higher in subjects suffering septic shock, compared to which APACHE-If score has merely slightly elevated. The fluctu- ation of serum PCT level paralleled with the variation of septic condition, whereas CRP did not. Conclusion Serum PCT level is closely correlated with the severity of sepsis, suggesting its big value in assisting physicians with accurate and timely severity deter- mination.

关 键 词：降钙素 C反应蛋白质 脓毒血症 病情监测 

分 类 号：R459.7[医药卫生—急诊医学]