心力衰竭合并心房纤颤患者血浆脑钠肽水平的变化及意义  

Changes and significances of BNP in the subjects of heart failure complicated with atrial fibrillation

作　　者：郭秀兰[1] 李晓军[2] 刘志军[3] 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001 [2]解放军第五医院,宁夏银川750004 [3]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2011年第10期944-946,共3页Ningxia Medical Journal

摘　　要：目的探讨血浆脑钠肽(BNP)水平在心力衰竭(心衰)合并心房纤颤(AF)患者中的变化及临床意义。方法将116例心衰患者按是否存在AF分为AF组、窦性心律(SR)组,再将AF组患者按照静息心室率控制在80次/min以下和以上分为两组,分别检测各组血浆BNP、NYHA分级以及左房、左室舒张末内径。结果 AF组血浆BNP浓度高于SR组,在相同的NYHA心功能分级亚组中,AF组BNP水平在心功能II级与III级组中显著高于SR组。心衰合并AF患者血浆BNP水平,与患者年龄(r=0.675,P<0.01)、AF持续时间(r=0.669,P<0.01)、左心房大小(r=0.734,P<0.01)、左室大小(r=0.846,P<0.01)均呈正相关;AF组中心室率控制与否两组BNP差异无统计学意义。结论心衰合并AF患者BNP水平明显升高,且与年龄、AF持续时间、左房、左室内径有关,AF患者心室率控制与否与BNP水平无明显相关。Objective To explore the changes and significances of BNP plasma concentration in the subjects of heart failure complicated with atrial fibrillation.Methods 116 patients with heart failure were divided into atrial fibrillation（AF） group and sinus rhythm（SR） group.Patients in the Group AF were divided into 2 groups depend on whether the heart rate was more than 80 bpm.Plasma BNP,NYHA classification and left atrial and left ventricular end diastolic diameter were measured in every subject in each group.Results Plasma BNP concentration in group SR was higher than that in group AF,in the same subgroup of NYHA class II and III,BNP level in group AF was significantly higher than that in group SR.Plasma BNP in patients with heart failure,the level of BNP were positively correlated with age（r = 0.675,P 0.01）,AF duration（r = 0.669,P 0.01）,left atrial size（r = 0.734,P 0.01）,left ventricular size（r = 0.846,P 0.01）,in group AF BNP had no significant difference in the two groups whether heart rate was more than 80 bpm or not.Conclusion BNP levels in patients with heart failure and atrial fibrillation are significantly higher than that in the group SR,and positively correlated with ages,AF duration,left atrial and left ventricular diameters.

关 键 词：心力衰竭 心房纤颤 脑钠肽 心室率 

分 类 号：R541.6[医药卫生—心血管疾病]