序贯法测定丙泊酚意识消失的半数有效量探讨  

Determination of the median effective dose of propofol for loss of consciousness by sequential experimental method

作　　者：尉静芳[1] 马汉祥[2] 陈学新[2] 徐婷婷[1] 毛晶晶[1] 熊祥生[1] 

机构地区：[1]宁夏医科大学,宁夏银川750004 [2]宁夏医科大学附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2011年第10期961-962,共2页Ningxia Medical Journal

基　　金：宁夏科技攻关项目(2010168);宁夏自然科学基金项目(NZ08114)

摘　　要：目的测定丙泊酚意识消失的半数有效量(ED50)和意识消失的全量,并探讨其与剂量关系。方法将48例患者分为两组(n=24),采用序贯给药法测定丙泊酚意识消失的ED50,意识消失全量的测定是以20mg/(kg.h)速度泵入丙泊酚直至患者眼睑反射消失,和对呼喊没有反应(意识消失指标)时停止泵药,记录泵入时间并计算丙泊酚用量。结果丙泊酚意识消失的ED50和全量分别是1.018mg/kg(95%CI,0.785-1.320 mg/kg)和(1.856±0.265)mg/kg。结论丙泊酚意识消失的ED50值为1.018mg/kg,意识消失的全量约为1.8 ED50。Objective To determine the dose of propofol at which 50% and 100% of patients fall into unconsciousness,and explore the relation between them.Methods 48patients were randomly divided equally into two groups（n=24）,50% of patients of loss of consciousness（LOC） for propofol were studied by sequential experimental method,and 100% of patients of LOC for propofol were studied by the method which propofol were continuously pumped through vein at the speed of 20mg/（kg·h） until the patients loss of responses to eyelash stimulation and verbal command.Results The median effective dose（ED50） and 100% effective dose of propofol for LOC（95% CI） were respectively 1.018（0.785-1.320） mg/kg and（1.856±0.265）mg/kg.Conclusion The ED50 of propofol for LOC is 1.018 mg/kg,and the 100% effective dose of propofol for LOC is 1.8 ED50.

关 键 词：丙泊酚 序贯试验法 半数有效量 意识 

分 类 号：R614[医药卫生—麻醉学]