右美托咪啶和咪达唑仑在心脏术后镇静作用的研究  

Comparison of dexmedetomidine and midazolam for sedation after cardiac surgery

作　　者：胡雪莲[1] 贾明[2] 赵勇[1] 高小芳[1] 

机构地区：[1]宁夏自治区人民医院,宁夏银川750001 [2]北京市安贞医院,北京100029

出　　处：《宁夏医学杂志》2011年第10期967-969,共3页Ningxia Medical Journal

摘　　要：目的观察右美托咪啶和咪达唑仑在心脏术后镇静中的作用。方法将200例心脏术后患者分成两组,男性125例,女性75例,年龄36-68岁,平均(56±18)岁。其中右美托咪啶组104例,右美托咪啶负荷量1μg/kg10min静脉推注,然后以0.2-0.7μg/(kg.h)持续静脉滴注;咪达唑仑组96例,咪唑安定0.05mg/kg 10min静脉推注,然后以0.02-0.1mg/(kg.h)持续静脉滴注,维持Ramssay评分2-3分,观察达到目标镇静范围的起效时间和用药前后、苏醒时的心率、呼吸﹑血压、血氧饱和度和中心静脉压的变化,苏醒时间和不良事件的发生率。结果在目标镇静(Ramssay)范围内,右美托咪啶组较咪达唑仑组起效时间快,苏醒时间快,谵妄、低血压、呼吸抑制及心动过缓等不良事件的发生率明显低于咪达唑仑组。结论右美托咪啶在心脏手术后患者应用是安全有效的。Objective To observe the comparison of dexmedetomidine and midazolam for sedation after cardiac surgery.Methods 200 patients after cardiac surgery were randomly assigned to one of two groups.One group received dexmedetomidine（1 μg/kg） over 10 min,followed immediately by a continuous infusion of 0.2-0.7 μg/kg/h,whereas the other group received midazolam（0.05 mg/kg） over 10 min,followed immediately by a continuous infusion of 0.02-0.1 mg/kg/h.Arterial blood pressures,heart rate, respiratory,oxygen saturation were measured before and after treatment.Results There was no significant difference in Ramssay score between two groups.Onset time and recovery time was faster in Dexmedetomidine groups,but incidence of delirium;hypotension,respiratory depression and bradycardia were significantly lower than those in midazolam group.Conclusion Dexmedetomidine is safe and effective in patients after cardiac surgery.

关 键 词：右美托咪啶 镇静 静脉滴注 心脏手术 

分 类 号：R614[医药卫生—麻醉学]