利多卡因和左旋布比卡因对大鼠臂丛神经功能的影响  

Effects of Lidocaine and Levobupivacaine on Brachial Plexus Nerve Function in Rats

作　　者：文婷[1] 杨晓慧 梅金红[3] 

机构地区：[1]南昌大学第一附属医院麻醉科,南昌330006 [2]高安市人民医院内科,江西高安330800 [3]南昌大学第一附属医院病理科,南昌330006

出　　处：《南昌大学学报（医学版）》2011年第8期57-59,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨利多卡因和左旋布比卡因对大鼠臂丛神经功能的影响。方法将54只SD大鼠按随机数字表法分为9组,每组6只:随机选取大鼠的一侧,生理盐水对照组(NS组)于腋鞘内注入生理盐水1mL,利多卡因L1-L4组于腋鞘内分别注入0.25%、0.50%、1.00%、2.00%利多卡因1mL,左旋布比卡因Z1-Z4组于腋鞘内分别注入0.25%、0.50%、1.00%、2.00%左旋布比卡因1mL。给药5d后,检测9组大鼠臂丛神经动作电位(AP)最大振幅、神经传导速度(NCV)的变化。结果与NS组相比,L2-L4组、Z3-Z4组臂丛神经AP的最大振幅降低,NCV减慢(P<0.05);组内比较:随着药物浓度递增,L2-L4组、Z3-Z4组臂丛神经AP的最大振幅降低,NCV减慢(P<0.05);相同浓度利多卡因和左旋布比卡因比较:利多卡因组臂丛神经AP的最大振幅降低,NCV减慢(P<0.05)。结论相同浓度利多卡因对臂丛神经功能的损害较左旋布比卡因更大。Objective To study the effects of lidocaine and levobupivacaine on brachial plexus nerve function in rats.Methods Fifty-four SD rats were randomly divided into nine groups,with 6 rats in each group.Axillary intrathecal injection on one side with 0.9% saline（1 mL）,0.25% lidocaine（1 mL）,0.50% lidocaine（1 mL）,1.00% lidocaine（1 mL）,2.00% lidocaine（1 mL）,0.25% levobupivacaine（1 mL）,0.50% levobupivacaine（1 mL）,1.00% levobupivacaine（1 mL） and 2.00% levobupivacaine（1 mL） was given to rats in NS group,L1 group,L2 group,L3 group,L4 group,Z1 group,Z2 group,Z3 group and Z4 group,respectively.The changes in the maximum amplitude of compound action potential（AP） and nerve conduction velocity（NCV） of brachial plexus nerve trunks were determined 5 days after injection.Results Compared with NS group,the maximum amplitude of AP and NCV decreased significantly in L2,L3,L4,Z3 and Z4 groups（P0.05）.Furthermore,the maximum amplitude of AP and NCV decreased with the increase of drug concentration.Compared with levobupivacaine,the maximum amplitude of AP and NCV were decreased by the same dose of lidocaine（P0.05）.Conclusion Lidocaine can cause more serious damage of brachial plexus nerve function than levobupivacaine at the same concentration.

关 键 词：利多卡因 左旋布比卡因 臂丛神经 神经功能 动物 实验 大鼠 

分 类 号：R332[医药卫生—人体生理学]