布地奈德混悬液雾化吸入配合猪肺磷脂防治新生儿呼吸窘迫综合征效果观察  

Efficacy of Budesonide Suspension for Inhalation combined with Poractant Alfa Injection in prevention of neonatal respiratory distress syndrome

作　　者：李兰[1] 范娟[1] 胡怡萍[2] 李茂军[1] 陈丽娜[1] 陈昌辉[1] 

机构地区：[1]四川省医学科学院.四川省人民医院儿科,四川成都610072 [2]四川大学华西第二医院,四川成都610041

出　　处：《实用医院临床杂志》2011年第6期141-142,共2页Practical Journal of Clinical Medicine

摘　　要：目的探讨布地奈德混悬液雾化吸入配合猪肺磷脂(商品名:固尔苏)防治新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)的效果。方法选择2009年9月至2010年9月我院新生儿病房收治的胎龄29～34周、生后2小时内入院的早产儿46例。按入院顺序单双号随机分成治疗组(A组)和对照组(B组)各23例,两组均给予综合治疗及猪肺磷脂120 mg气管内滴入,在此基础上,A组给予布地奈德混悬液0.5 mg雾化吸入,盐酸氨溴索针剂10 mg/kg静脉滴注,每8小时1次,连用5天;B组仅给予盐酸氨溴索针剂10 mg/kg静脉滴注,每8小时1次,连用5天。检测两组早产儿入院第1、2、3天动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)水平及发生NRDS的例数。结果两组PaO2、PaCO2第1天差异无统计学意义,第2、3天差异有统计学意义(P<0.05);A组无NRDS发生,B组发生NRDS4例,发生率17%,两组比较差异有统计学意义(P<0.05)。结论布地奈德混悬液雾化吸入配合猪肺磷脂能较快改善早产儿通气及换气功能,改善血气指标,提高机体供氧,有效预防NRDS的发生,降低早产儿的病死率。Objective To explore the efficacy of Budesonide Suspension for Inhalation combined with Poractant Alfa Injection in the prevention and treatment of neonatal respiratory distress syndrome（NRDS）.Methods Forty-six preterm infants two hours after birth,with gestational age from 29 to 34 weeks,were admitted in the newborn nursery of our hospital from Sep 2009 to Sep 2010 and randomly divided into two groups according to orders of admission.Each group was involved 23 preterm infants and was given comprehensive treatment and Poractant Alfa Injection 120 mg by tracheal instillation.Group A was discharged on Budesonide Suspension for Inhalation 0.5 mg/kg plus Ambroxol Hydrochloride Injection 10 mg/kg IV q.8 h for 5 days.Group B was only discharged on Ambroxol Hydrochloride Injection 10 mg/kg IV q.8 h for 5 days.Arterial partial pressure of oxygen（PaO2）,arterial partial pressure of carbon dioxide（PaCO2） in the 1st,2nd,3rd day and the cases of NRDS were observed.Results PaO2 and PaCO2 of the two groups in the 1st day had no significant difference（P0.05）,while those in the 2nd and 3rd day had significant difference（P0.05）.No NRDS occurred in group A,while 4 cases occurred in group B,with incidence rate as 17%（NS,P0.05）.Conclusions The use of Budesonide Suspension for Inhalation combined with Poractant Alfa Injection can improve the ventilation function,blood gas and body oxygen in preterm infants,effectively prevent the occurrence of NRDS,and reduce the mortality in preterm infants.

关 键 词：早产儿 布地奈德混悬液 猪肺磷脂 呼吸窘迫综合征 

分 类 号：R722.12[医药卫生—儿科] R916.697[医药卫生—临床医学]