缩宫素与米索前列醇应用于产后出血的效果比较  

Effect comparison of oxytocin and misoprostol in postpartum hemorrhage

作　　者：李莉君 

机构地区：[1]湖南省攸县第二人民医院妇产科,湖南攸县412300

出　　处：《中国当代医药》2011年第29期74-75,共2页China Modern Medicine

摘　　要：目的:比较米索前列醇、缩宫素及二者联合应用于产后出血的效果和安全性。方法:取348例2010年1～12月在本院产科住院足月分娩的产妇,均无妊娠合并症及并发症,均无心﹑肺﹑肝﹑肾等慢性疾病,对前列腺素类药物无禁忌,且无近期应用前列腺抑制药物史。将其随机分为Ⅰ(单用缩宫素)、Ⅱ(单用米索前列醇)、Ⅲ(二者联合应用)3组各116例,对比3组在产后2、24h的出血情况,产后出血发生率,血细胞比容(Hct)和血红蛋白(Hb)的变化情况。结果:3组之间的一般情况差异无统计学意义(P均>0.05)。3组产后出血发生率,Ⅲ组<Ⅱ组<Ⅰ组;2、24h的出血情况,均是Ⅲ组最少,Ⅰ组最多,差异有统计学意义(P均<0.05);Hct下降幅度Ⅰ组最大,Ⅲ组最小,差异有统计学意义(P<0.05);3组第三产程时间差异无统计学意义(P均>0.05)。Hb下降幅度Ⅰ组最大,Ⅲ组最小,差异有统计学意义(P<0.05)。安全性方面,Ⅰ组出现不良反应14例,Ⅱ组出现15例,Ⅲ组出现17例。结论:联合应用缩宫素和米索前列醇可以有效预防产后出血,效果比单用其中任何一种药物都要明显,除了出现个别轻微不良反应外,安全性尚可。Objective： To compare the efficacy and safety of misoprostol, oxytocin and combination used in postpartum hemorrhage. Methods： 348 patients in our delivery of maternal obstetric hospital within the past year term, which had no complications of pregnancy, had no unintentional, lung, liver, kidney and other chronic diseases, the prostaglandin drug without taboo, and no recent applications of the prostate on drug history. Randomly divided into Ⅰ （oxytocin alone）, Ⅱ （misoprostol alone）, Ⅲ （both combined） groups, compared in the post-2 h, 24 h of the bleeding, the incidence of postpartum hemorrhage, hematocrit （Hct） and hemoglobin （Hb） changes. Results： The general situation among the three groups had no significant differences （P0.05）. The incidence of postpartum hemorrhage three groups, Ⅲ groupⅡ group Ⅰ group; 2 h, 24 h of the bleeding, Ⅲ group was the least, Ⅰ group was the most, the difference was statistically significant （P0.05）; Ⅰ group was the maximum, Ⅲ group the smallest about Hct decreasing, the difference was statistically significant （P0.05）; three group in the third stage of labor had no significant difference （P0.05）. Ⅰ group was the maximum decrease in Hb, Ⅲ was the smallest group, the difference was statistically significant （P0.05）. In terms of security, Ⅰ group had 14 cases of adverse reactions, Ⅱ group had 15 cases, Ⅲ group had 17 cases. Conclusion： The combined using of oxytocin and misoprostol to prevent postpartum hemorrhage is better than any drug alone obviously. The adverse reactions are mild. It is worthy of promotion.

关 键 词：缩宫素 米索前列醇 产后出血 效果比较 

分 类 号：R714.461[医药卫生—妇产科学]